AI Article Synopsis
- Scientists are trying to find ways to increase brown fat cells in people to help with obesity and diabetes.
- Brown fat is important because it helps burn energy, but obese and diabetic people have less of it.
- Researchers have created a new method to turn special stem cells into brown fat cells, which can help study how brown fat develops and works in humans.
Article Abstract
Increasing brown adipose tissue (BAT) mass and activation is a therapeutic strategy to treat obesity and complications. Obese and diabetic patients possess low amounts of BAT, so an efficient way to expand their mass is necessary. There is limited knowledge about how human BAT develops, differentiates, and is optimally activated. Accessing human BAT is challenging, given its low volume and anatomical dispersion. These constraints make detailed BAT-related developmental and functional mechanistic studies in humans virtually impossible. We have developed and characterized functionally and molecularly a new chemically defined protocol for the differentiation of human pluripotent stem cells (hPSCs) into brown adipocytes (BAs) that overcomes current limitations. This protocol recapitulates step by step the physiological developmental path of human BAT. The BAs obtained express BA and thermogenic markers, are insulin sensitive, and responsive to β-adrenergic stimuli. This new protocol is scalable, enabling the study of human BAs at early stages of development.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7940445 | PMC |
| http://dx.doi.org/10.1016/j.stemcr.2021.01.013 | DOI Listing |
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