AI Article Synopsis
- Nine new compounds called pleionosides M-U and 12 known compounds were extracted from the pseudobulbs of a certain plant.
- The structures of these compounds were determined using advanced techniques like high-resolution electrospray ionization mass spectrometry (HRESIMS) and nuclear magnetic resonance (NMR).
- Some of these new compounds demonstrated significant protective effects on liver cells against specific toxicities, improving cell viability substantially compared to the control group.
Article Abstract
Nine new glucosyloxybenzyl 2-hydroxy-2-isobutylsuccinates, pleionosides M-U (-), and 12 known compounds (-) were isolated from the pseudobulbs of . Their structures and absolute configurations were established through a combination of HRESIMS and NMR data and supported by physical and chemical methods. Compounds , , , and showed significant in vitro hepatoprotective activity against d-galactosamine (d-GalN)-induced toxicity in HL-7702 cells with increasing cell viability by 27%, 22%, 19%, and 31% compared to the model group (cf. bicyclol, 14%) at 10 μM, respectively. Compounds , , and exhibited moderate hepatoprotective activity against -acetyl--aminophenol (APAP)-induced toxicity in HepG2 cells with increasing cell viability by 9%, 16%, and 12% compared to the model group (cf. bicyclol, 9%) at 10 μM, respectively.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11215813 | PMC |
| http://dx.doi.org/10.1021/acs.jnatprod.0c01117 | DOI Listing |
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