AI Article Synopsis
- Eosinophil recruitment to the skin is a key feature of bullous pemphigoid, and understanding the signals leading to this recruitment is crucial for developing treatments.
- The study found that galectin-9 levels were significantly higher in the serum and skin lesions of bullous pemphigoid patients compared to controls, suggesting its involvement in the disease.
- Despite increased galectin-9 levels, there was no correlation found with the disease's severity, indicating its role may be more complex in the context of bullous pemphigoid.
Article Abstract
Massive recruitment of eosinophils into the dermis is a hallmark of bullous pemphigoid pathogenesis. Identifying the chemoattractant(s) guiding eosinophils into the skin in bullous pemphigoid is a prerequisite to thera-peutic targeting of eosinophil recruitment. Galectin -9 is a potent chemoattractant for eosinophils, but its potential role in bullous pemphigoid is unknown. The aim of this study was to determine the expression levels of galectin-9 in serum and skin of patients with bullous pemphigoid. Galectin-9 levels were significantly elevated in serum of patients with bullous pemphigoid compared with age- and sex-matched controls, but did not correlate with disease activity assessed with the Bullous Pemphigoid Disease Area Index. Galectin-9 expression was also increased in lesional skin of patients with bullous pemphigoid, and was expressed predominantly in eosinophils, neutrophils and keratinocytes. In conclusion, these results support the notion that galectin-9 may play a role in the patho-genesis of bullous pemphigoid.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366699 | PMC |
| http://dx.doi.org/10.2340/00015555-3771 | DOI Listing |
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