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Trimethyl Borate-Catalyzed, Solvent-Free Reductive Amination. | LitMetric

Trimethyl Borate-Catalyzed, Solvent-Free Reductive Amination.

J Org Chem

Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907-2084, United States.

Published: March 2021

Solvent-free reductive amination of aldehydes and ketones with aliphatic and aromatic amines in high-to-excellent yields has been achieved with sub-stoichiometric trimethyl borate as promoter and ammonia borane as reductant.

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.joc.0c02143DOI Listing

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