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Expanding science skills: teaching tissue culture, data analysis, and reporting through imaging the actin cytoskeleton.
J Microbiol Biol Educ
August 2024
Department of Biology, University of York, York, United Kingdom.
Within the eukaryotic cell, the actin cytoskeleton is a crucial structural framework that maintains cellular form, regulates cell movement and division, and facilitates the internal transportation of proteins and organelles. External cues induce alterations in the actin cytoskeleton primarily through the activation of Rho GTPases, which then bind to a diverse array of effector proteins to promote the local assembly or disassembly of actin. We have harnessed the extensively studied functions of RhoA in the dynamics of the actin cytoskeleton to craft a practical series for Stage 2 Biology students.
View Article and Find Full Text PDFPAK-dependent regulation of actin dynamics in breast cancer cells.
Int J Biochem Cell Biol
May 2022
School of Cancer and Pharmaceutical Sciences, Kings College London, London UK. Electronic address:
Metastatic Breast Cancer has a poor 25% survival rate and currently there are no clinical therapeutics which target metastasis. 'Migrastatics' are a new drug class which target migration pathway effector proteins in order to inhibit cancer cell invasion and metastasis. The p21-activated kinases (PAKs) are essential drivers of breast cancer cell migration and invasion through their regulation of actin cytoskeletal dynamics.
View Article and Find Full Text PDFThe effects of dual-task interference in predicting turn-ends in speech and music.
Brain Res
October 2021
Department of Psychology, University of Edinburgh, UK.
Determining when a partner's spoken or musical turn will end requires well-honed predictive abilities. Evidence suggests that our motor systems are activated during perception of both speech and music, and it has been argued that motor simulation is used to predict turn-ends across domains. Here we used a dual-task interference paradigm to investigate whether motor simulation of our partner's action underlies our ability to make accurate turn-end predictions in speech and in music.
View Article and Find Full Text PDFHoning in on the effectors of oxidative stress in the asthmatic lung: oxidised phosphatidylcholines.
Eur Respir J
February 2021
Center for Translational Medicine, Dept of Medicine, Thomas Jefferson University, Philadelphia, PA, USA
Cytosolic Gram-negative bacteria prevent apoptosis by inhibition of effector caspases through lipopolysaccharide.
Nat Microbiol
February 2020
Institute for Medical Microbiology, Immunology and Hygiene, Centre for Molecular Medicine Cologne and Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases, University of Cologne, Cologne, Germany.
The cytosolic appearance and propagation of bacteria cause overwhelming cellular stress responses that induce apoptosis under normal conditions. Therefore, successful bacterial colonization depends on the ability of intracellular pathogens to block apoptosis and to safeguard bacterial replicative niches. Here, we show that the cytosolic Gram-negative bacterium Shigella flexneri stalls apoptosis by inhibiting effector caspase activity.
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