AI Article Synopsis
- Immunotherapies like immune checkpoint blockade and adoptive cell transfer have greatly improved cancer treatment but understanding tumor resistance remains challenging.
- New technologies, particularly single-cell RNA sequencing, are providing detailed insights into the tumor microenvironment and immune system that traditional bulk genomics can't capture.
- This technique has identified important factors and cell types that influence tumor behavior, paving the way for the development of more effective immunotherapies in the future.
Article Abstract
Immunotherapies such as immune checkpoint blockade and adoptive cell transfer have revolutionized cancer treatment, but further progress is hindered by our limited understanding of tumor resistance mechanisms. Emerging technologies now enable the study of tumors at the single-cell level, providing unprecedented high-resolution insights into the genetic makeup of the tumor microenvironment and immune system that bulk genomics cannot fully capture. Here, we highlight the recent key findings of the use of single-cell RNA sequencing to deconvolute heterogeneous tumors and immune populations during immunotherapy. Single-cell RNA sequencing has identified new crucial factors and cellular subpopulations that either promote tumor progression or leave tumors vulnerable to immunotherapy. We anticipate that the strategic use of single-cell analytics will promote the development of the next generation of successful, rationally designed immunotherapeutics.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754680 | PMC |
| http://dx.doi.org/10.1084/jem.20201574 | DOI Listing |
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