Gq-Gi-PLCβ in cells: More than the sum of its reconstituted parts.

Cell Calcium

Cancer Discovery Team, Wilkie Laboratory, Department of Pharmacology, UT Southwestern Medical Center, 6001 Forest Park Drive, Dallas, TX 75390, USA.

Published: March 2021

The recent paper by Pfeil et al., "Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs", opens another path from biochemical in vitro reconstitution to understanding the complex regulation of calcium signaling inside the cell.

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Source
http://dx.doi.org/10.1016/j.ceca.2020.102340DOI Listing

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