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Comparison of antidepressant effects of azafan, tianeptine, and paroxetine.
Bull Exp Biol Med
July 2009
Laboratory for Creation, Testing, Distribution, Manufacturing, and Marketing of Drugs, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Russia.
Antidepressant activity of Russian product Azafen (pipofezine) and foreign products Paroxetine and Tianepine was compared using behavioral despair test (Porsolt test) and forced swimming test in a container with wheels (Nomura). Azafen significantly shortened the duration of depressive state in both tests. The results suggest that Azafen exhibits pronounced antidepressant activity, superior to that of the reference drugs.
View Article and Find Full Text PDFIn experiments in white mice and rats the antidepressants pyrazidol (pirlindole), moclobemide and especially tetrindole possess anticalcium activity in tests of calcium chloride-induced lethality in mice and arrhythmia in rats. Tetrindole is as active as verapamil. Imipramine, azaphen and incazane were not active in these experiments.
View Article and Find Full Text PDF[Nerve growth factor and the state of serotoninergic system in endogenous depression and mental retardation].
Vestn Ross Akad Med Nauk
February 1993
Platelet parameters of the serotonin system were studied in patients with endogenous depressions and children with late documented phenylketonuria (PKU) before and after antidepressive therapy. There was a significant decrease in the rate of back platelet uptake of 3H-serotonin and an increase in the sensitivity of serotonin receptors to serotonin in the patients before therapy and normalization of these parameters after therapy. The normalization correlated with clinical improvement in patients with endogenous depression.
View Article and Find Full Text PDFThe experiments on albino rats demonstrated that antidepressants pyrazidol, imipramine, incazane, moclobemide and to a lesser degree azaphen reduce the amnesic effects of electroshock and scopolamine in the rats with the acquired conditioned reaction of passive avoidance. The studied antidepressants decrease also the disturbing action of alcohol on the learning of rats of the conditioned reaction of active avoidance.
View Article and Find Full Text PDF[Effects of antidepressive agents on tolerance of hypoxia and physical exercise].
Biull Eksp Biol Med
August 1991
In experiments on mice and rats we studied the influence of antidepressants on hypoxic and physical tolerance. The antidepressants pyrazidol, azaphen, imipramine and moclobemide as well as the nootropic drug piracetam prolonged the life of animals in conditions of hypoxic and hemic hypoxia and increased the survival rate of rats in circulatory hypoxia. In experiments on mice antidepressants increased also the time of swimming.
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