The radiological risk assessment and the definition of the radioprotection physical surveillance program applied to a 250 kW (thermal power) research nuclear reactor operated by a large Italian public body. Useful elements for the prevention of personnel exposures, classification criteria for workers, risk reduction methods and optimization of exposures, most common criticalities in plant activities. Analysis of the main operations related to the activities of irradiation and scientific research with an eye to the needs of researchers and one to the indications of prevention. Consolidated intervention methods for ordinary activities and for emergency situations. Detailed examination of the possible unforeseen events or accidents initiators, stopping the assessment at the definition of the source terms related to emergencies inside the plant. Nuclear and conventional causes of accidents and analysis of the radiological consequences. Indications for in-depth-defense and long-term monitoring of the safety of workers, individuals of population and the environment.
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Clin Colorectal Cancer
December 2024
Medical University Vienna, Department of Medicine I, Vienna, Austria. Electronic address:
Background: The efficacy of trifluridine/tipiracil (FTD/TPI) + bevacizumab compared to FTD/TPI for treatment of refractory metastatic colorectal cancer (mCRC) was demonstrated in the SUNLIGHT trial. This analysis of SUNLIGHT investigated the impact of treatment with FTD/TPI + bevacizumab on patient quality of life (QoL) and Eastern Cooperative Oncology Group performance status (ECOG PS).
Methods: Questionnaires (EORTC QLQ-C30 and EQ-5D-5L) and ECOG PS assessments were conducted at baseline and on Day 1 of each treatment cycle.
Environ Res
January 2025
Department of Clinical Pharmacology, Pharmacy and Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark; Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark; OPEN Patient Data Explorative Network, Odense, Denmark.
Background: Over the past decade, the use of organophosphate insecticides including chlorpyrifos has faced increasing restrictions due to health concerns, leading to a rise in use of pyrethroids. Concerns about neurodevelopmental insults following pyrethroids exposure exist, but few studies have examined the long-term effects of childhood exposure to chlorpyrifos and pyrethroids on IQ.
Objective: To investigate the prospective associations between pyrethroids and chlorpyrifos exposure at age 5 years and IQ scores assessed at age 7.
Sci Total Environ
January 2025
University College London, Central House, 14 Upper Woburn Place, London WC1H 0NN, UK. Electronic address:
This paper investigates heritage climatology through global analysis of damage functions for collections, aiming to learn about the reliability of these functions and the field itself. It addresses the growing interest in geospatial analysis of climate hazards for cultural heritage, proposing parameters that refine climate-related deterioration processes. Using global daily climate data from 1991 to 2020, the study assesses damage functions reliant on temperature and relative humidity inputs, including damage functions for paper and metals, alongside indices for humidity fluctuations and mould growth.
View Article and Find Full Text PDFJ Am Heart Assoc
January 2025
Dijon Stroke Registry, EA7460, Pathophysiology and Epidemiology of Cardiocerebrovascular Diseases (PEC2) University of Burgundy France.
Background: This study aimed to assess attack rates of ischemic cerebrovascular events (CVEs) in a population-based registry and to estimate the current and projected burden of the disease in whole France.
Methods And Results: All cases of ischemic CVE (including ischemic stroke and transient ischemic attack) were prospectively identified through the population-based Dijon Stroke Registry, France (2013-2020). Annual attack rates and temporal trends were assessed.
World J Diabetes
January 2025
Department of Internal Medicine, University of Tabuk, Tabuk 51941, Tabuk, Saudi Arabia.
Patients admitted with prediabetes and atrial fibrillation are at high risk for major adverse cardiac or cerebrovascular events independent of confounding variables. The shared pathophysiology between these three serious but common diseases and their association with atherosclerotic cardiovascular risk factors establish a vicious circle culminating in high atherogenicity. Because of that, it is of paramount importance to perform risk stratification of patients with prediabetes to define phenotypes that benefit from various interventions.
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