In pattern classification, we may have a few labeled data points in the target domain, but a number of labeled samples are available in another related domain (called the source domain). Transfer learning can solve such classification problems via the knowledge transfer from source to target domains. The source and target domains can be represented by heterogeneous features. There may exist uncertainty in domain transformation, and such uncertainty is not good for classification. The effective management of uncertainty is important for improving classification accuracy. So, a new belief-based bidirectional transfer classification (BDTC) method is proposed. In BDTC, the intraclass transformation matrix is estimated at first for mapping the patterns from source to target domains, and this matrix can be learned using the labeled patterns of the same class represented by heterogeneous domains (features). The labeled patterns in the source domain are transferred to the target domain by the corresponding transformation matrix. Then, we learn a classifier using all the labeled patterns in the target domain to classify the objects. In order to take full advantage of the complementary knowledge of different domains, we transfer the query patterns from target to source domains using the K-NN technique and do the classification task in the source domain. Thus, two pieces of classification results can be obtained for each query pattern in the source and target domains, but the classification results may have different reliabilities/weights. A weighted combination rule is developed to combine the two classification results based on the belief functions theory, which is an expert at dealing with uncertain information. We can efficiently reduce the uncertainty of transfer classification via the combination strategy. Experiments on some domain adaptation benchmarks show that our method can effectively improve classification accuracy compared with other related methods.
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http://dx.doi.org/10.1109/TCYB.2021.3052536 | DOI Listing |
Mol Ther
January 2025
Brown Center for Immunotherapy. Indiana University School of Medicine. 975 W. Walnut St., IB554A, Indianapolis, IN 46202. Electronic address:
Chimeric Antigen Receptor (CAR) T cell therapy has revolutionized cancer treatment and is now being explored for other diseases, such as autoimmune disorders. While the tumor microenvironment (TME) in cancer is often immunosuppressive, in autoimmune diseases, the environment is typically inflammatory. Both environments can negatively impact CAR T cell survival: the former through direct suppression, hypoxia, and nutrient deprivation, and the latter through chronic T cell receptor (TCR) engagement, risking exhaustion.
View Article and Find Full Text PDFCell Biosci
January 2025
School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong S.A.R., China.
Background: Pathogenic or null mutations in WRN helicase is a cause of premature aging disease Werner syndrome (WS). WRN is known to protect somatic cells including adult stem cells from premature senescence. Loss of WRN in mesenchymal stem cells (MSCs) not only drives the cells to premature senescence but also significantly impairs the function of the stem cells in tissue repair or regeneration.
View Article and Find Full Text PDFEnviron Res
January 2025
Institute of Science and Technology, São Paulo State University (UNESP), Av. Três de Março, 511, Alto da Boa Vista, 18087-180 Sorocaba, SP, Brazil. Electronic address:
This study provides comprehensive overview of the current level, sources and human exposure risk to hazardous polycyclic aromatic hydrocarbons (PAHs), polybrominated diphenyl ethers (PBDEs), and polychlorinated biphenyls (PCBs) in South American outdoor air. Research documents were obtainable for only 6 countries within the target period (2014 - 2024). For all contaminants, urban concentrations exceeded that of rural/remote locations.
View Article and Find Full Text PDFEnviron Pollut
January 2025
Department of Civil Engineering, Khulna University of Engineering & Technology, Khulna, 9203, Bangladesh; Department of Civil Engineering, University of Creative Technology Chittagong, Chattogram, 4212, Bangladesh.
Criteria air pollutant exposure impacts human health through various pathways. Preterm birth (PTB) is one of the major adverse birth outcomes (ABO) associated with such exposure. Although numerous global and regional studies have been conducted on this issue, few have recently investigated the impact of major criteria air pollutant exposure on PTBs in Bangladesh, one of the world's most polluted countries with the highest relative PTB rate.
View Article and Find Full Text PDFJ Environ Manage
January 2025
Department of Environmental Economics & Management, The Hebrew University of Jerusalem, Israel.
The Jordan Valley (JV) is a critical region where the interplay of water, energy, food, and ecosystem (WEFE) dynamics presents both challenges and opportunities for sustainable development and climate change mitigation and adaptation. In such a transboundary river basin with acute nexus problems and a long history of conflicts, it is essential that conscious efforts are made to pluralize the debate and actively encourage stakeholders' empowerment, participation and fair collaboration in strategic planning. An integrated framework for participatory strategic planning in the WEFE nexus is proposed, which has been developed in the context of the JV case study.
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