Babesiosis is a tick-borne parasitic disease of humans and livestock that has dramatically increased in frequency and geographical range over the past few decades. Infection of cattle often causes large economic losses, and human infection can be fatal in immunocompromised patients. Unlike for malaria, another disease caused by hemoprotozoan parasites, limited treatment options exist for infections. As epigenetic regulation is a promising target for new antiparasitic drugs, we screened 324 epigenetic inhibitors against blood stages and identified 75 (23%) and 17 (5%) compounds that displayed ≥90% inhibition at 10 and 1 μM, respectively, including over a dozen compounds with activity in the low nanomolar range. We observed differential activity of some inhibitor classes against and parasites and identified pairs of compounds with a high difference in activity despite a high similarity in chemical structure, highlighting new insights into the development of epigenetic inhibitors as antiparasitic drugs.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022219 | PMC |
| http://dx.doi.org/10.1021/acsinfecdis.0c00853 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Large-scale molecular survey for piroplasmids in Iberian wild carnivores.
Parasitol Res
December 2024
Animal Health Department, Faculty of Veterinary Medicine, Universidad Complutense of Madrid, Madrid, Spain.
Piroplasmids are vector-borne hemoprotozoan parasites belonging to the phylum Apicomplexa that are of veterinary and medical importance. Wild carnivores are hosts for diverse piroplasmids, some of which are highly pathogenic for domestic dogs and cats. A large-scale survey including samples from 244 individuals belonging to eleven different species that were opportunistically obtained between 1993 and 2015 in four Autonomous Regions in Spain were tested for piroplasmid DNA with two different nested-PCR assays targeting the 18S rRNA gene.
View Article and Find Full Text PDFNovel insights into antioxidant status, gene expression, and immunohistochemistry in an animal model infected with camel-derived Trypanosoma evansi and Theileria annulata.
Parasit Vectors
November 2024
Department of Parasitology, Faculty of Veterinary Medicine, Cairo University, Giza, 1221, Egypt.
Article Synopsis
- The study focuses on two blood protozoa, Trypanosoma evansi and Theileria annulata, affecting camels in Egypt and highlights the lack of knowledge regarding camel infections and immune responses.
- Molecular methods confirmed the presence of these parasites, with significant adverse effects on immune function and increased oxidative stress observed in both camels and experimental mice.
- The research findings include the first molecular identification of these pathogens in Egypt, demonstrating upregulation of immune response and stress markers, indicating their pathogenic potential.
First Report of (Neumann) in Oklahoma, USA.
Pathogens
October 2024
Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USA.
Article Synopsis
- The Asian longhorned tick, originally from East Asia, has become invasive in regions such as Australia, New Zealand, and the United States, rapidly spreading since 2017.
- Its ability to reproduce without mating and feed on various hosts contributes to its fast expansion, particularly affecting cattle where it can cause economic losses.
- This report details the first finding of this tick in Oklahoma, expanding its known range further west in the U.S., although no pathogenic DNA was found in samples from affected cattle.
Dry LAMP: A point of care diagnostics for diagnosis of bovine tropical theileriosis.
J Vector Borne Dis
July 2024
National Institute of Veterinary Epidemiology and Disease Informatics, Yelhanka, Bengaluru, India.
Background Objectives: Theileriosis is an important tick-bome hemoprotozoan disease of cattle which causes severe economic loss due to morbidity and mortality. A diagnostic test having high sensitivity, specificity and easy application at the field level is the need of the hour. In this regard Loop-mediated isothermal amplification (LAMP) is proven to be a sensitive, easy and time efficient method.
View Article and Find Full Text PDFMolecular prevalence and genotypic diversity of Theileria equi and Babesia caballi infecting horses in Kyrgyzstan.
Parasitol Int
October 2024
National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan; WOAH Reference Laboratories for Bovine Babesiosis and Equine Piroplasmosis, National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan. Electronic address:
Equine piroplasmosis is caused by Theileria equi and Babesia caballi, which are hemoprotozoan parasites. Understanding the epidemiology and genotypes of T. equi and B.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!