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Real-world evaluation of select adverse drug reactions and healthcare utilization associated with parenteral Ibuprofen and ketorolac in adult and pediatric patients.
Front Pain Res (Lausanne)
January 2025
Cumberland Pharmaceuticals, Nashville, TN, United States.
Introduction: Intravenous non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used in healthcare settings, but their comparative safety and resource utilization impacts remain understudied. This study aimed to compare adverse drug reactions (ADRs) and healthcare resource utilization (HCRU) between patients receiving IV-ibuprofen versus IV/IM ketorolac.
Methods: A retrospective, longitudinal analysis was conducted using an all-payer database, examining records from January 1, 2014, to June 3, 2023.
Licensure Actions Against Psychiatric Clinicians: A Cohort Analysis of National Practitioner Database Reports.
J Psychiatr Pract
January 2025
University of Cincinnati Medical Center, Cincinnati, OH.
Objective: To examine trends and predictors of administrative actions against psychiatric clinicians' licenses between 2002 and 2022.
Methods: Data from the National Practitioner Data Bank (NPDB) identified 6400 disciplinary actions against psychiatric clinicians' licenses. Linear trend models assessed the trends of disciplinary actions across mental/physical health, licensing/legal issues, and unprofessional conduct.
Chronic kidney disease progression in patients with previous type 2 diabetes and/or hypertension: a population-based cohort study from primary care in Spain.
BMJ Open
January 2025
Disease, Cardiovascular Risk and Lifestyles in Primary Care Research Group (MARCEVAP), L'Hospitalet de Llobregat, Barcelona, Spain
Objectives: To evaluate whether between hypertension and type 2 diabetes (T2D)-established drivers of chronic kidney disease (CKD) progression-one might be more strongly associated with CKD progression than the other.
Design: Cohort study using a primary care database (electronic health records).
Setting: Primary care in Catalonia, Spain.
Functional characterization of eQTLs and asthma risk loci with scATAC-seq across immune cell types and contexts.
Am J Hum Genet
January 2025
Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, USA; Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA. Electronic address:
cis-regulatory elements (CREs) control gene transcription dynamics across cell types and in response to the environment. In asthma, multiple immune cell types play an important role in the inflammatory process. Genetic variants in CREs can also affect gene expression response dynamics and contribute to asthma risk.
View Article and Find Full Text PDFInternational Society of Sports Nutrition Position Stand: Long-Chain Omega-3 Polyunsaturated Fatty Acids.
J Int Soc Sports Nutr
December 2025
Department of Health and Human Performance, Nova Southeastern University, Davie, FL, USA.
Position Statement: The International Society of Sports Nutrition (ISSN) presents this position based on a critical examination of the literature surrounding the effects of long-chain omega-3 polyunsaturated fatty acid (ω-3 PUFA) supplementation on exercise performance, recovery, and brain health. This position stand is intended to provide a scientific foundation for athletes, dietitians, trainers, and other practitioners regarding the effects of supplemental ω-3 PUFA in healthy and athletic populations. The following conclusions represent the official position of the ISSN: Athletes may be at a higher risk for ω-3 PUFA insufficiency.
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