(, -) is considered as the epitome of theory and the experience collected of the doctors treating smallpox in Ming dynasty. There exists some mistakes and lack of detailed introductions about it and its author Zhu Yilin in some bibliographies. Zhu's style name is"Jixiang", and"Yingwo"is his art name. His most active time was during the reigns of Wanli and Chongzhen emperors. He learned medicine because of his illness and became good at treating smallpox. After failing to pass the Imperial examinations, he focused on practicing medicine. Zhu Yilin's printed medical works include (, ), and his medical records. There are the preface of 1st Year of Tianqi Reign wood-block edition, and 2 copied manuscripts, one in Japan and the other in Taiwan. Zhu's descendant Zhu Fa and Zhu Cun collected his works above and compiled as one book, renamed its name to during Qianlong and Daoguang Reign and printed it in 1826, which is called the Daoguang Gengletang edition. Some reference books and textbooks mistake it as compiled in 1619, printed in 1743 or 1765. In addition, (, ) in was mainly based on (, ), and extracted many books like (, ).
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http://dx.doi.org/10.3760/cma.j.cn112155-20200530-00081 | DOI Listing |
J Med Virol
January 2025
National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Oncolytic viruses are emerging as promising cancer therapeutic agents, with several poxviruses, including vaccinia virus (VACV) and myxoma virus, showing significant potential in preclinical and clinical trials. Modified vaccinia virus Ankara (MVA), a laboratory-derived VACV strain approved by the FDA for mpox and smallpox vaccination, has been shown to be incapable of replicating in human cells unless zinc finger antiviral protein (ZAP) is repressed. Notably, ZAP deficiency is prevalent in various cancer types.
View Article and Find Full Text PDFJ Med Virol
December 2024
SR Sanjeevani Hospital, Kalyanpur, Siraha, Nepal.
Mpox, formerly known as monkeypox, has re-emerged as a significant global health concern, particularly during the widespread outbreak of 2022. As an orthopoxvirus related to the eradicated smallpox virus, mpox has been primarily managed with smallpox vaccines and treatments, including the antiviral agent Tecovirimat. This systematic review aims to evaluate the effectiveness and safety of Tecovirimat in treating mpox, focusing on its use during the 2022 outbreak, especially among high-risk populations, including men who have sex with men and people living with HIV.
View Article and Find Full Text PDFHist Cienc Saude Manguinhos
December 2024
Doutor, História Social/Universidade Federal do Paraná. Curitiba - PR - Brasil
This study reflects on the efforts to disseminate and administer the smallpox vaccine in the Brazilian province of Paraná between 1853 and 1863, taking a circulation-based perspective. Chronologically, the first milestone is the founding of Paraná and the second is the drafting of the first regulations for vaccination in the province. This research draws on the assumptions of translocal microhistory and the theoretical conceptions expounded by Kapil Raj and Fa-ti Fan.
View Article and Find Full Text PDFHist Cienc Saude Manguinhos
December 2024
Professora, Curso de História/Universidade Estadual do Ceará. Fortaleza - CE - Brasil
The article draws a parallel between two pathological phenomena with great social impact in different settings: the smallpox epidemic in Ceará, northeastern Brazil, between 1900 and 1905, and the covid-19 pandemic in Brazil between 2020 and 2022. Despite the historical and temporal distance between these two episodes, there are some significant similarities in the ways they were conducted politically, especially with regard to the use of fake news and misinformation on the emergency of implementing mass vaccination. The analysis makes extensive use of press reports concerning the covid-19 pandemic and writings by the pharmacist Rodolfo Teófilo, a key figure in the smallpox vaccination campaign in Ceará.
View Article and Find Full Text PDFCureus
November 2024
Public Health, Health Services Academy, Islamabad, PAK.
Background Monkeypox (Mpox) is a virulent disease caused by orthopoxvirus. Mpox is emerging as a major global health threat. Currently, more than 100 countries are facing outbreaks.
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