Cell Volume Regulation in the Epidermis.

Cell Physiol Biochem

Department of Dermatology, Venerology and Allergology, University Hospital Frankfurt, Frankfurt am Main, Germany,

Published: February 2021

In order to cope with external stressors such as changes in humidity and temperature or irritating substances, the epidermis as the outermost skin layer forms a continuously renewing and ideally intact protective barrier. Under certain circumstances, this barrier can be impaired and epidermal cells have to counteract cell swelling or shrinkage induced by osmotic stress via regulatory volume decrease (RVD) or increase (RVI). Here, we will review the current knowledge regarding the molecular machinery underlying RVD and RVI in the epidermis. Furthermore, we will discuss the current understanding how cell volume changes and its regulators are associated with epidermal renewal and barrier formation.

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http://dx.doi.org/10.33594/000000330DOI Listing

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