AI Article Synopsis
- The study aimed to assess cases of new or reactivated uveitis in patients receiving biologic therapy, focusing on their characteristics.* -
- A multicenter review identified 16 patients with underlying conditions like ankylosing spondylitis and rheumatoid arthritis, who developed uveitis linked to biologic drugs such as etanercept and adalimumab.* -
- Findings indicated that biologic agents often induce uveitis that manifests as granulomatous disease, with several patients showing signs consistent with sarcoid uveitis.*
Article Abstract
Purpose/objectives: to evaluate new onset uveitis or reactivated uveitis by biologic agents and characterize their features.
Materials And Methods: This is a multicenter, retrospective case series. Patients under biologic therapy were included if they developed uveitis for the first time or experienced intraocular inflammation which was different in location or laterality to previous inflammation.
Results: Sixteen patients were identified. The underlying disorders included ankylosing spondylitis, juvenile idiopathic arthritis, rheumatoid arthritis, and Behçet's Disease. The biologic agents associated with a first episode of uveitis (n = 11) or with a new recurrence of uveitis (n = 5) were etanercept, adalimumab, abatacept, infliximab, and golimumab. Sarcoidosis based on bihilar lymphadenopathy, other computer tomography-findings, or biopsy was diagnosed in five patients under therapy with etanercep, adalimumab, and abatacept. Additionally, seven patients developed clinical changes in their uveitis pattern, suggesting sarcoid uveitis.
Conclusions: Biologic treatment-induced uveitis often presents as granulomatous disease.
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| http://dx.doi.org/10.1080/09273948.2020.1850799 | DOI Listing |
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