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Early extracorporeal membranous oxygenation and burn excision in severe burn and inhalation injury.
Scars Burn Heal
December 2024
Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Article Synopsis
- ECMO (extracorporeal membranous oxygenation) is explored as a treatment option for patients with severe ARDS, particularly in burn cases where previous experience is limited.
- A case study details a 40-year-old woman with significant burns and severe inhalation injury who was placed on veno-venous ECMO for over 21 days while undergoing multiple surgical procedures and receiving extensive blood product transfusions.
- The report emphasizes the challenges and complexities of managing ECMO support during burn excision surgery, highlighting the need for further research on patient management strategies and the timing of interventions in such cases.
A Rare Case of Congenital Factor XIII Deficiency Secondary to Hyperconsumption: A Case Report.
Cureus
November 2024
General Medicine, Saveetha Medical College, Chennai, IND.
Acquired Factor XIII (FXIII) deficiency is a rare condition often associated with underlying medical conditions or medications. We present a case of a 23-year-old male, who presented with prolonged bleeding from a traumatic ulcer site on his left leg. Initial laboratory investigations revealed a severe deficiency in FXIII activity (30%) and antigen levels (25%), with no evidence of congenital disorders or other underlying pathologies.
View Article and Find Full Text PDFComprehensive Analysis of Purpura Fulminans as an Uncommon Postoperative Complication: A Case Series.
Cureus
November 2024
General Surgery, Srinivas Institute of Medical Sciences and Research Centre, Mangalore, IND.
Background: Acute infectious purpura fulminans (AIPF) is a rare but potentially fatal postoperative complication characterised by rapidly progressing disseminated intravascular coagulation (DIC), widespread purpura, and multi-organ dysfunction. Despite its severe and critical outcomes, the literature on this condition in the postoperative context is limited.
Objectives: This study aimed to analyse and evaluate the incidence, clinical presentation, laboratory findings, management strategies, and outcomes of postoperative AIPF in patients who underwent various surgical procedures.
Early high-dose cryoprecipitate to reduce mortality in adult patients with traumatic haemorrhage: the CRYOSTAT-2 RCT with cost-effectiveness analysis.
Health Technol Assess
November 2024
NHS Blood and Transplant and Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK.
Background: Traumatic haemorrhage is common after severe injury, leading to disability and death. Cryoprecipitate, a source of fibrinogen, may improve outcomes for patients with traumatic haemorrhage.
Objective: To investigate the effects of early fibrinogen supplementation in the form of 3 pools (15 units, approximately 6 g of fibrinogen) of cryoprecipitate on 28-day mortality.
Fluid resuscitation in trauma: What you need to know.
J Trauma Acute Care Surg
January 2025
From the Comparative Effectiveness and Clinical Outcomes Research Center (N.K.D., J.K., R.C.), and Division of Trauma and Acute Care Surgery (N.K.D., R.C.), Riverside University Health System Medical Center, Moreno Valley; Department of Surgery (N.K.D., R.C.), Loma Linda University School of Medicine, Loma Linda, California; and Division of Trauma (J.K.), Ajou University School of Medicine, Suwon, South Korea.
There have been numerous changes in resuscitation strategies for severely injured patients over the last several decades. Certain strategies, such as aggressive crystalloid resuscitation, have largely been abandoned because of the high incidence of complications and worsening of trauma-induced coagulopathy. Significant emphasis has been placed on restoring a normal coagulation profile with plasma or whole blood transfusion.
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