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| http://dx.doi.org/10.4103/ijo.IJO_2960_20 | DOI Listing |
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Abdominal Applications of Photon-Counting CT.
Br J Radiol
October 2024
Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115.
Photon-counting computed tomography (PCCT) has shown promising advancements in abdominal imaging in clinical use. Though more peer-reviewed primary literature is needed, this commentary explores PCCT's potential applications, focusing on enhancing diagnostic accuracy, optimizing radiation dose management, and improving patient care. PCCT offers improved spatial and contrast resolution, lower image noise, and reduced radiation dose.
View Article and Find Full Text PDFTowards an evidence-based integrative lighting score: a proposed multi-level approach.
Ann Med
December 2024
Centre for Chronobiology, Psychiatric Hospital of the University of Basel, Basel, Switzerland.
Human circadian clocks are synchronized daily with the external light-dark cycle and entrained to the 24-hour day. There is increasing evidence that a lack of synchronization and circadian entrainment can lead to adverse health effects. Beyond vision, light plays a critical role in modulating many so-called non-visual functions, including sleep-wake cycles, alertness, mood and endocrine functions.
View Article and Find Full Text PDFImportance: Despite widespread availability and consensus on its advantages for detailed imaging of geographic atrophy (GA), spectral-domain optical coherence tomography (SD-OCT) might benefit from automated quantitative OCT analyses in GA diagnosis, monitoring, and reporting of its landmark clinical trials.
Objective: To analyze the association between pegcetacoplan and consensus GA SD-OCT end points.
Design, Setting, And Participants: This was a post hoc analysis of 11 614 SD-OCT volumes from 936 of the 1258 participants in 2 parallel phase 3 studies, the Study to Compare the Efficacy and Safety of Intravitreal APL-2 Therapy With Sham Injections in Patients With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (OAKS) and Study to Compare the Efficacy and Safety of Intravitreal APL-2 Therapy With Sham Injections in Patients With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (DERBY).
Decidual leukocytes respond to African lineage Zika virus infection with mild anti-inflammatory changes during acute infection in rhesus macaques.
Front Immunol
March 2024
Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI, United States.
Zika virus (ZIKV) can be vertically transmitted during pregnancy resulting in a range of adverse pregnancy outcomes. The decidua is commonly found to be infected by ZIKV, yet the acute immune response to infection remains understudied . We hypothesized that African-lineage ZIKV infection induces a pro-inflammatory response in the decidua.
View Article and Find Full Text PDFSelf-Supervised Learning for Improved Optical Coherence Tomography Detection of Macular Telangiectasia Type 2.
JAMA Ophthalmol
March 2024
Department of Ophthalmology, University of Washington, Seattle.
Importance: Deep learning image analysis often depends on large, labeled datasets, which are difficult to obtain for rare diseases.
Objective: To develop a self-supervised approach for automated classification of macular telangiectasia type 2 (MacTel) on optical coherence tomography (OCT) with limited labeled data.
Design, Setting, And Participants: This was a retrospective comparative study.
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