Fatty acid desaturase 1 () polymorphisms alter fatty acid content in subcutaneous adipose tissue (SAT); however, existing evidence is limited and conflicting regarding the association between variants and SAT inflammatory status. To advance this area, we conducted an exploratory study to investigate whether the common rs174537 polymorphism in was associated with immune cell profiles in abdominal and femoral SAT in individuals with obesity. gene expression and immune cell profiles in SAT depots were assessed by qPCR and flow cytometry, respectively. Although gene expression was associated with genotype, no associations were observed with immune cell profiles in either depot. Our study provides additional evidence that rs174537 in has minimal impact on inflammatory status in obese SAT.
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| http://dx.doi.org/10.1080/21623945.2021.1888470 | DOI Listing |
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