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Neonatal inflammation and near-term white matter microstructure in infants born very preterm.
Neuroimage Rep
December 2024
Department of Pediatrics, Division of Developmental-Behavioral Pediatrics, Stanford University, Stanford, CA, USA.
Background: Severe neonatal inflammatory conditions in very preterm infants (VPT: <32 weeks gestational age, GA) are linked to adverse neurodevelopmental outcomes. Differences in white matter (WM) microstructure of the corpus callosum (CC) have been observed at age 6 in VPT children with a history of severe neonatal inflammation. The goal of this study was to determine whether these CC differences can be detected at term-equivalent age using diffusion MRI (dMRI), and whether neonatal inflammation is associated with altered WM in additional tracts implicated in the encephalopathy of prematurity.
View Article and Find Full Text PDFSimultaneous treatment with palm-LEAP2(1-14) and feeding high-fat diet attenuates liver lipid metabolism but not obesity: Sign of selective resistance to palm-LEAP2(1-14).
Mol Cell Endocrinol
February 2025
Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic. Electronic address:
Liver-enriched antimicrobial peptide 2 (LEAP2) is a natural antagonist/inverse agonist of ghrelin receptor GHSR. Its truncated palmitoylated analog palm-LEAP2(1-14) promised anti-obesity properties because it exhibited favourable stability and an acute anorexigenic effect in our previous studies. Here we demonstrate desirable palm-LEAP2(1-14) pharmacokinetics, with significant levels of the peptide persisting in mouse blood 3 h after its subcutaneous administration.
View Article and Find Full Text PDFDysgraphia Following the Resection of a Left Parietal Glioma.
Acta Neurochir Suppl
November 2024
Instituto de Ciências da Saúde & Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, Brazil.
We report herein the case of a 41-year-old man operated on for a small inferior parietal lobule ganglioglioma with a sleep-awake-sleep protocol and language mapping to avoid major speech disorders. Postoperatively, however, writing disturbance was characterized by persistent graphemic errors that lasted for about 8 months. The topic is discussed in light of recent literature, exploring the possible relationship between writing difficulties and disconnections produced by a combination of resecting supramarginal gyrus components and interrupting arcuate fasciculus fibers.
View Article and Find Full Text PDFDynamic Ultrasound Assessment of Celiac Artery Flow Velocity in Median Arcuate Ligament Syndrome Diagnosis.
Am J Case Rep
October 2024
Department of Clinical Engineering, Faculty of Health Care Sciences, Jikei University of Health Care Sciences, Osaka, Japan.
BACKGROUND Median arcuate ligament syndrome (MALS) poses a considerable challenge in terms of diagnosis due to its manifestation of diverse symptoms linked to constriction of the median arcuate ligament surrounding the celiac artery. The present study introduces an earlier diagnostic modality using ultrasound measurements of the flow velocity of the celiac artery during the inspiratory and expiratory phases, with the latter being higher than the former, to avoid prolonged follow-up of postprandial symptomatology. CASE REPORT A 46-year-old female patient presented with acute postprandial abdominal pain, which was alleviated by analgesic medication.
View Article and Find Full Text PDFShellfishing, sea levels, and the earliest Native American villages (5000-3800 yrs. BP) of the South Atlantic Coast of the U.S.
Sci Rep
September 2024
Department of Anthropology, American Museum of Natural History, New York, NY, USA.
Article Synopsis
- * These sites reveal some of the earliest year-round Native American villages in the Eastern Woodlands of North America, containing artifacts like pottery and faunal remains along with the shells.
- * Research shows that these communities thrived for over 1000 years, adapting to changing sea levels that influenced their fishing practices, particularly targeting oyster reefs.
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