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Playing a serious game to increase fertility awareness: perceptions of adolescents, parents and teachers.
Hum Fertil (Camb)
December 2025
Instituto Superior Miguel Torga, Coimbra, Portugal.
Infertility is increasing globally, affecting one in six adults due to factors like delayed childbearing and lifestyle changes. Despite the recognition of the importance of increasing fertility awareness, levels remain low. This study evaluated the perceptions of 'FActs!', a serious game aimed at improving adolescents' fertility awareness.
View Article and Find Full Text PDFEfficacy of cartilage-targeted IGF-1 in a mouse model of growth hormone insensitivity.
Front Endocrinol (Lausanne)
January 2025
Section on Growth and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Health, Bethesda, MD, United States.
Recombinant human IGF-1 is used to treat severe primary IGF-1 deficiency, but this treatment requires twice-daily injection, often does not fully correct the growth deficit, and has important off-target effects. We therefore sought to target IGF-1 to growth plate cartilage by generating fusion proteins combining IGF-1 with single-chain human antibody fragments that target matrilin-3, a cartilage matrix protein. We previously showed that this cartilage-targeting IGF-1 fusion protein (CV1574-1) promoted growth plate function in a GH-deficient (lit) mouse model.
View Article and Find Full Text PDFA safe and effective treatment for refractory malignant ascites: the use of pigtail catheters.
Pol J Radiol
December 2024
Dr. Lütfi Kırdar City Hospital, Kartal, Turkey.
Purpose: Recurrent malignant ascites is a common and challenging condition in cancer patients, often lacking a standardized treatment protocol. Small-scale studies in the literature have been insufficient to establish a treatment standard. The aim of our study was to investigate the effectiveness and safety of pigtail peritoneal catheter application in the treatment of malignant ascites.
View Article and Find Full Text PDFInvestigating the relationship between happiness and self-esteem with self-efficacy in the clinical performance of midwives working in medical centers and comprehensive health services.
J Educ Health Promot
December 2024
Nursing and Midwifery Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Background: Self-efficacy is one of the factors affecting correct performance, especially in emergency and stressful situations. The mental state of people can affect their performance. The present study was conducted with the aim of determining the relationship between self-esteem and happiness with self-efficacy in the clinical practice of midwives working in medical centers and comprehensive health services in Isfahan city.
View Article and Find Full Text PDFThe role of diagnostic modalities in differentiating hypertensive heart disease and hypertrophic cardiomyopathy: strategies in adults for potential application in paediatrics.
Cardiol Young
January 2025
Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Hypertensive heart disease and hypertrophic cardiomyopathy both lead to left ventricular hypertrophy despite differing in aetiology. Elucidating the correct aetiology of the presenting hypertrophy can be a challenge for clinicians, especially in patients with overlapping risk factors. Furthermore, drugs typically used to combat hypertensive heart disease may be contraindicated for the treatment of hypertrophic cardiomyopathy, making the correct diagnosis imperative.
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