AI Article Synopsis
- Parainfluenza virus type 5 (PIV-5) affects both animals and humans, with Canine PIV-5 (CPIV-5) being a major cause of respiratory illness in dogs globally.
- A study in Thailand from 2015 to 2018 found 5.6% of nasal swab samples from dogs with respiratory issues tested positive for CPIV-5 using RT-PCR.
- Whole genome sequencing of selected CPIV-5 samples revealed that the strains from Thailand are closely related to those from China and Korea, suggesting the need for expanded surveillance to better understand CPIV-5's distribution and potential zoonotic risks.
Article Abstract
Parainfluenza virus type 5 (PIV-5) causes respiratory infection in several animal species and humans. Canine parainfluenza virus type 5 (CPIV-5) causes respiratory disease in domestic dogs worldwide. In this study, we conducted a cross-sectional survey of CPIV-5 in dogs with respiratory symptoms from small animal hospitals in Thailand from November 2015 to December 2018. Our results showed that 32 out of 571 nasal swab samples (5.6%) were positive for CPIV-5 by RT-PCR specific to the NP gene. To characterize the viruses, three representative CPIV-5 were subjected to whole genome sequencing, and an additional ten CPIV-5 were subjected to HN, F, SH and V/P gene sequencing. Pairwise sequence comparison and phylogenetic analysis showed that Thai CPIV-5 was closely related to the CPIV-5 isolated from China and Korea. In conclusion, this study constitutes a whole genome characterization of CPIV-5 from dogs in Thailand. The surveillance of CPIV-5 should be further investigated at a larger scale to determine the dynamics, distribution and potential zoonotic transmission of CPIV-5.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887266 | PMC |
| http://dx.doi.org/10.1038/s41598-021-83323-9 | DOI Listing |
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