AI Article Synopsis
- Aggressive brain tumors, specifically glioblastoma, rely on their surrounding environment, and certain tumor cells play crucial roles in their progression.
- Research identified a new type of tumor-associated cell, TAMEP, which has a myeloid-like expression profile and appears during glioblastoma growth; these cells do not originate from traditional immune sources but are derived from CNS-resident progenitors that express SOX2.
- Disabling these SOX2-positive progenitor cells leads to a significant decrease in both the size and blood vessel formation of glioblastomas, emphasizing TAMEP's importance in tumor development.
Article Abstract
Aggressive brain tumors like glioblastoma depend on support by their local environment and subsets of tumor parenchymal cells may promote specific phases of disease progression. We investigated the glioblastoma microenvironment with transgenic lineage-tracing models, intravital imaging, single-cell transcriptomics, immunofluorescence analysis as well as histopathology and characterized a previously unacknowledged population of tumor-associated cells with a myeloid-like expression profile (TAMEP) that transiently appeared during glioblastoma growth. TAMEP of mice and humans were identified with specific markers. Notably, TAMEP did not derive from microglia or peripheral monocytes but were generated by a fraction of CNS-resident, SOX2-positive progenitors. Abrogation of this progenitor cell population, by conditional Sox2-knockout, drastically reduced glioblastoma vascularization and size. Hence, TAMEP emerge as a tumor parenchymal component with a strong impact on glioblastoma progression.
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| http://dx.doi.org/10.1016/j.cels.2021.01.002 | DOI Listing |
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