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A SONAR report on Nirmatrelvir/ritonavir-associated rebound COVID-19: Using new databases for evaluating new diseases.
PLoS One
September 2024
City of Hope Comprehensive Cancer Center and the Beckman Research Institute, Duarte, California, United States of America.
Introduction: In May 2022, the Centers for Disease Control and Prevention disseminated an alert advising that "a few" persons with Nirmatrelvir/ritonavir (NM/R)-associated rebound of COVID-19 infection had been identified. Three case reports appearing as pre-print postings described the first cases. Analyses in March 2023 by NM/R's manufacturer and the Food and Drug Administration (FDA) reported no association between NM/R and COVID-19 rebound in a large phase 3 randomized clinical trial.
View Article and Find Full Text PDFExploring the current dynamics of preprints.
Curr Med Res Opin
May 2024
Department of Agricultural and Biological Engineering, University of Illinois at Urbana-Champaign, Urbana-Champaign, Illinois, USA.
Preprints are non-peer-reviewed and publicly available articles for open and transparent research communication. Preprint servers host the submission of such manuscripts, and despite the presence of established preprint servers, their numbers have continued to rise in recent times. A steep increasing pattern in posted preprints and their accommodating servers has been observed over the last decade.
View Article and Find Full Text PDFArtificial intelligence in endoscopy related to inflammatory bowel disease: A systematic review.
Indian J Gastroenterol
February 2024
Medical Gastroenterology, Asian Institute of Gastroenterology, Somajiguda, Hyderabad, 500 082, India.
Background And Objectives: In spite of rapid growth of artificial intelligence (AI) in digestive endoscopy in lesion detection and characterization, the role of AI in inflammatory bowel disease (IBD) endoscopy is not clearly defined. We aimed at systematically reviewing the role of AI in IBD endoscopy and identifying future research areas.
Methods: We searched the PubMed and Embase database using keywords ("artificial intelligence" OR "machine learning" OR "computer-aided" OR "convolutional neural network") AND ("inflammatory bowel disease" OR "ulcerative colitis" OR "Crohn's") AND ("endoscopy" or "colonoscopy" or "capsule endoscopy" or "device assisted enteroscopy") between 1975 and September 2023 and identified 62 original articles for detailed review.
Improving Access to Care for Patients Taking Opioids for Chronic Pain: Recommendations from a Modified Delphi Panel in Michigan.
J Pain Res
July 2023
Division of General Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Article Synopsis
- About 5-8 million Americans are on long-term opioid therapy for chronic pain, but stricter prescribing policies are causing increased abrupt discontinuations, leading to problems like untreated pain and potential use of illegal opioids.
- A study involving a panel of 24 experts from various fields in Michigan aimed to create recommendations to enhance patient access to opioid therapy through workshops and discussions.
- The panel produced 11 key recommendations focusing on three themes: reimbursement reform (highest priority), provider education, and addressing racial disparities in care, with specific suggestions like improving payment for complex chronic pain treatment and bundling payments for comprehensive care.
Associations between obstructive sleep apnea and COVID-19 infection and hospitalization among US adults.
J Clin Sleep Med
July 2023
Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts.
Study Objectives: Medical comorbidities increase the risk of severe COVID-19 infection. In some studies, obstructive sleep apnea (OSA) has been identified as a comorbid condition that is associated with an increased prevalence of COVID-19 infection and hospitalization, but few have investigated this association in a general population. This study aimed to answer the following research question: In a general population, is OSA associated with increased odds of COVID-19 infection and hospitalization and are these altered with COVID-19 vaccination?
Methods: This was a cross-sectional survey of a diverse sample of 15,057 US adults.
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