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Difunctionalized pillar[5]arene-based polymer nanosheets for photodynamic therapy of infection. | LitMetric

Difunctionalized pillar[5]arene-based polymer nanosheets for photodynamic therapy of infection.

J Mater Chem B

State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, People's Republic of China. and College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou, China.

Published: March 2021

AI Article Synopsis

  • Bacterial infections are a major global health threat, necessitating the urgent development of safe and effective antibacterial agents.
  • Researchers created stable polymer nanosheets from a specific chemical combination for photodynamic antibacterial therapy, which effectively targets Staphylococcus aureus (SA).
  • These nanosheets not only kill bacteria by generating reactive oxygen species under light but also show minimal toxicity to human cells, indicating their potential for real-world applications in fighting infections.

Article Abstract

Bacterial infections pose severe threats to global public health security. Developing antibacterial agents with both high efficiency and safety to handle this problem has become a top priority. Here, highly stable and effective polymer nanosheets have been constructed by the covalent co-assembly of a pillar[5]arene derivative and metalloporphyrin for photodynamic antibacterial therapy (PDAT). The monolayer nanosheets are strongly positively charged and thus capable of binding with Staphylococcus aureus (SA) through electrostatic interactions. Additionally, the nanosheets can be activated to generate reactive oxygen species (ROS) under white-light irradiation, and exhibit satisfactory antibacterial performance towards SA. More importantly, cell viability assays demonstrate that the nanosheets show little to no cytotoxicity impact on mammalian cells even when the concentrations are much higher than those employed in the antibacterial studies. The above results suggest that the polymer nanosheets could be an effective antibacterial agent to overcome bacterial infections and hold a broad range of potential applications in real life.

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Source
http://dx.doi.org/10.1039/d0tb02786cDOI Listing

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