The budding deuteriodifluoromethyl group (CFD) is a potentially significant functional group in medicinal chemistry. Herein, we investigated -BuOK-catalyzed H/D exchange reaction of difluoromethylarenes in DMSO- solution. The method provides excellent deuterium incorporation at the difluoromethyl group. Meanwhile, the effect of a trace amount of DO in DMSO- solution on the deuteration reaction was also investigated.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.joc.0c02827 | DOI Listing |
Publication Analysis
Top Keywords
h/d exchange
8
exchange reaction
8
reaction difluoromethylarenes
8
dmso- solution
8
base-catalyzed h/d
4
difluoromethylarenes budding
4
budding deuteriodifluoromethyl
4
deuteriodifluoromethyl group
4
group cfd
4
cfd functional
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!