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Anti-spike S1 receptor-binding domain antibodies against SARS-CoV-2 persist several months after infection regardless of disease severity. | LitMetric

AI Article Synopsis

  • - A study enrolled 111 COVID-19 patients to evaluate immune response related to IgG antibodies targeting the viral nucleoprotein and spike protein, revealing varying severity levels among participants (28% mild/moderate, 42% severe, 30% critical) and age (median 57 years).
  • - Results indicated that patients with critical disease exhibited higher peak anti-NP and anti-S1RBD IgG levels during hospitalization compared to those with milder illnesses.
  • - Six months post-discharge, a significant decrease in anti-NP IgG was observed, while anti-S1RBD IgG showed only a modest decline, indicating prolonged immune response and supporting vaccination as an effective strategy against COVID-19. *

Article Abstract

Data regarding the immunological memory and long-time kinetics of immunoglobulin (IgG) against viral nucleoprotein (NP) and spike protein S1 receptor-binding domain (S1RBD) of Severe Acute Respiratory Syndrome-associated Coronavirus 2 (SARS-CoV-2) are lacking. All consecutive COVID-19 patients admitted to our Clinic between March 1, 2020, and May 1, 2020, who were tested at hospital admission for anti-S1RBD and anti-NP IgG were enrolled. Serum samples were tested for anti-SARS-CoV-2 antibodies with the use of two commercially available enzyme-linked immunosorbent assays. Results are expressed as optical density measurements at 450 nm (OD ). Overall, 111 patients were included; the median (q1-q3) age was 57 (49-73) years, 59 (53%) males. According to disease severity, 31 (28%), 47 (42%), and 33 (30%) patients were considered affected by mild/moderate, severe, and critical SARS-CoV-2 infection, respectively. During hospitalization, patients with the critical disease showed a higher peak value of both anti-NP (median OD : 3.66 vs. 3.06 vs. 3.00 respectively, p = .043) and anti-S1RBD IgG (median OD : 2.33 vs. 1.6 vs. 0.91, respectively, p < .001). By testing 48 subjects 6 months or above from discharge, a significant decrease of anti-NP IgG was observed (r: -0.5838; p < .0001), whereas anti-S1RBD IgG showed only a modest reduction (r: -0.1507; p = .0647). Accordingly, 10 (21%) and 2 (4%) patients had a negative serological status for anti-NP and anti-S1RBD IgG, respectively; no association with clinical severity was found. IgGs against SARS-CoV-2 persisted several months after discharge, regardless of disease severity, suggesting that vaccination could be a valid strategy to fight the pandemic.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8014088PMC
http://dx.doi.org/10.1002/jmv.26878DOI Listing

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