Interleukin-6 (IL-6) binds to the IL-6 receptor (IL-6R) subunit, related to autoimmune diseases and cytokine storm in COVID-19. In this study, we performed systematic evolution of ligands by exponential enrichment and identified a novel RNA aptamer. This RNA aptamer not only bound to IL-6R with a dissociation constant of 200 n m, but also inhibited the interaction of IL-6R with IL-6.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7799299 | PMC |
| http://dx.doi.org/10.1093/bbb/zbaa124 | DOI Listing |
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