AI Article Synopsis
- The study aimed to examine the impact of hydrocortisone treatment on hospital outcomes for infants with persistent pulmonary hypertension of the newborn (PPHN) who received inhaled nitric oxide.
- Out of 2,743 infants studied, 30% received hydrocortisone; however, there was no significant difference in outcomes like death, chronic lung disease (CLD), or the need for oxygen at discharge, despite hydrocortisone's association with increased use of certain medical interventions.
- Interestingly, in infants with meconium aspiration syndrome, hydrocortisone use correlated with a reduction in oxygen requirements at discharge, suggesting that further research is needed to fully understand its effects.
Article Abstract
Objective: Characterize association between hydrocortisone receipt and hospital outcomes of infants with persistent pulmonary hypertension of the newborn (PPHN).
Study Design: Cohort study of infants ≥34 weeks with PPHN who received inhaled nitric oxide at <7 days of age (2010-2016). We generated propensity scores, and performed inverse probability-weighted regression to estimate hydrocortisone effect on outcomes: death, chronic lung disease (CLD), oxygen at discharge.
Results: Of 2743 infants, 30% received hydrocortisone, which was associated with exposure to mechanical ventilation, sedatives, paralytics, or vasopressors (p < 0.001). There was no difference in death, CLD, or oxygen at discharge. In infants with meconium aspiration syndrome, hydrocortisone was associated with decreased oxygen at discharge (odds ratio 0.56; 95% confidence interval 0.21, 0.91).
Conclusions: There was no association between hydrocortisone receipt and death, CLD, or oxygen at discharge in our cohort. Prospective studies are needed to evaluate the effectiveness of hydrocortisone in infants with PPHN.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052278 | PMC |
| http://dx.doi.org/10.1038/s41372-021-00943-9 | DOI Listing |
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