Macroscopic T-wave alternans in a patient presenting with hepatic encephalopathy.

J Electrocardiol

Department of Cardiology, School of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. Electronic address:

Published: July 2021

Macroscopic T-wave alternans (TWA) is the beat-to-beat variation in the amplitude or shape of the T wave on a surface electrocardiogram (ECG) and known to be a harbinger of impending malignant ventricular arrhythmias such as polymorphic ventricular tachycardia. We herein report a case with hepatic encephalopathy, who developed TWA, followed by polymorphic ventricular tachycardia.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jelectrocard.2021.01.011DOI Listing

Publication Analysis

Top Keywords

macroscopic t-wave
8
t-wave alternans
8
hepatic encephalopathy
8
polymorphic ventricular
8
ventricular tachycardia
8
alternans patient
4
patient presenting
4
presenting hepatic
4
encephalopathy macroscopic
4
alternans twa
4

Similar Publications

Background: Little is known about the role of atrial arrhythmias (AAs) in triggering Torsade de Pointes (TdP) in patients with long QT syndrome (LQTS). The aim of this study was to examine the contribution of AAs to the development of TdP in acquired LQTS patients.

Methods: The initiation patterns of 81 episodes of TdP obtained from 34 consecutive acute acquired LQTS patients (14 men, median age, 69 years; median QTc, 645.

View Article and Find Full Text PDF

The spiked helmet sign (SHS) is a rare electrocardiographic marker associated with an increased risk of lethal ventricular tachyarrhythmias and sudden cardiac death. To our knowledge, this is the first study aimed at reviewing recent research progress on this electrocardiogram (ECG) pattern to summarize its electrophysiological mechanisms, epidemiological features, clinical characteristics, and clinical significance. SHS formation is attributed to sympathetic hyperactivity, which mediates increased dispersion of ventricular repolarization, leading to marked QT prolongation and macroscopic T-wave alternans.

View Article and Find Full Text PDF

T-wave inversion through inhomogeneous voltage diffusion within the FK3V cardiac model.

Chaos

April 2024

Department of Physics, and Institute of Theoretical and Computational Physics, University of Crete, Heraklion 70013, Greece.

The heart beats are due to the synchronized contraction of cardiomyocytes triggered by a periodic sequence of electrical signals called action potentials, which originate in the sinoatrial node and spread through the heart's electrical system. A large body of work is devoted to modeling the propagation of the action potential and to reproducing reliably its shape and duration. Connection of computational modeling of cells to macroscopic phenomenological curves such as the electrocardiogram has been also intense, due to its clinical importance in analyzing cardiovascular diseases.

View Article and Find Full Text PDF

Functional and clinical characterization of a novel homozygous KCNH2 missense variant in the pore region of Kv11.1 leading to a viable but severe long-QT syndrome.

Gene

March 2024

National Reference Center for Inherited Arrhythmias of Lyon, Department of Cardiac Electrophysiology, Louis Pradel Hospital, Hospices Civils de Lyon, Lyon, France; University of Lyon, Claude Bernard Lyon 1 University, MeLiS, CNRS UMR 5284, INSERM U1314, Institut NeuroMyoGène, Lyon 69008, France. Electronic address:

Article Synopsis
  • The study identifies a novel homozygous missense variant (p.Gly603Ser) in the KCNH2 gene linked to severe long-QT syndrome (LQTS) in a family context.
  • The research employs functional analysis using Xenopus oocytes to compare the effects of this variant with the wild-type version of the gene, revealing significant differences in electrical properties.
  • The findings suggest that while this variant leads to severe yet survivable LQTS in homozygous individuals, it causes a milder Type 2 LQTS in heterozygous carriers, marking a unique discovery in the genetic understanding of heart rhythm disorders.
View Article and Find Full Text PDF
Article Synopsis
  • Arrhythmogenic left ventricular cardiomyopathy (ALVC) is a serious heart condition linked to dangerous heart rhythms, and it's increasingly recognized for its impact on the left ventricle, with diagnosis relying on cardiac imaging and genetic testing.
  • A case study involved a 28-year-old woman and her uncle, both with heart issues; they underwent extensive testing that revealed abnormalities consistent with ALVC, including reduced heart function and genetic mutations.
  • Early diagnosis is crucial for managing ALVC to prevent sudden cardiac death, with treatment options potentially including implantable cardioverter defibrillators (ICDs) based on genetic findings and patient discussions about care plans.*
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!