AI Article Synopsis
- TRP channels in airway sensory nerves help detect various sensory inputs like chemicals and temperatures, playing a vital role in our respiratory defense mechanisms.
- They react to both harmful inhaled substances and naturally occurring chemicals in the body, contributing to nerve activity and reflex responses.
- Recent studies highlight key TRP channels (TRPA1, TRPV1, TRPV4, TRPM8) as significant players in the symptoms and development of acute and chronic airway diseases.
Article Abstract
Transient Receptor Potential (TRP) channels expressed in specific subsets of airway sensory nerves function as transducers and integrators of a diverse range of sensory inputs including chemical, mechanical and thermal signals. These TRP sensors can detect inhaled irritants as well as endogenously released chemical substances. They play an important role in generating the afferent activity carried by these sensory nerves and regulating the centrally mediated pulmonary defense reflexes. Increasing evidence reported in recent investigations has revealed important involvements of several TRP channels (TRPA1, TRPV1, TRPV4 and TRPM8) in the manifestation of various symptoms and pathogenesis of certain acute and chronic airway diseases. This mini-review focuses primarily on these recent findings of the responses of these TRP sensors to the biological stresses emerging under the pathophysiological conditions of the lung and airways.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988689 | PMC |
| http://dx.doi.org/10.1016/j.neulet.2021.135719 | DOI Listing |
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