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Adiponectin and leptin exert antagonizing effects on proliferation and motility of papillary thyroid cancer cell lines. | LitMetric

AI Article Synopsis

  • * The study examined how Acrp30 and leptin affect thyroid cancer cell behavior, finding that Acrp30 inhibits cell proliferation and motility, while leptin has the opposite effect.
  • * Combined treatment of Acrp30 and leptin shows antagonistic effects on cell migration and invasion, indicating their potential as therapeutic targets and biomarkers for thyroid cancer management.

Article Abstract

Adiponectin (Acrp30) and leptin, adipokines produced and secreted mainly by the adipose tissue, are involved in human carcinogenesis. Thyroid carcinomas are frequent endocrine cancers, and several evidences suggest that they are correlated with obesity. In this study, we first analyzed the expression levels and prognostic values of Acrp30, leptin, and their receptors in thyroid cancer cells. Then, we investigated the role of Acrp30 and leptin in proliferation, migration, and invasion. We found that Acrp30 treatment alone inhibits cell proliferation and cell viability in a time and dose-dependent manner; leptin alone does not influence thyroid cancer cells (BCPAP and K1) proliferation, but the combined treatment reverts Acrp30-induced effects on cell proliferation. Additionally, through wound healing and Matrigel Matrix invasion assays, we unveiled that Acrp30 inhibits thyroid cancer cell motility, while leptin induces the opposite effect. Importantly, in the combined treatment, Acrp30 and leptin exert antagonizing effects on papillary thyroid cancer cells' migration and invasion in both BCPAP and K1 cell lines. Highlights of these studies suggest that Acrp30 and leptin could represent therapeutic targets and biomarkers for the management of thyroid cancer.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121733PMC
http://dx.doi.org/10.1007/s13105-021-00789-xDOI Listing

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