AI Article Synopsis
- Researchers developed short ceramide analogs that can be activated by light and modified using click chemistry.
- These analogs have better cell permeability than longer versions, proven by mass spectrometry and imaging techniques.
- The short analogs allow for optical control of apoptosis and serve as light-responsive substrates for sphingomyelin synthase 2, showing reversed light dependency compared to longer variants.
Article Abstract
We report short ceramide analogs that can be activated with light and further functionalized using azide-alkyne click chemistry. These molecules, termed , exhibit increased cell permeability compared to their long-chain analogs as demonstrated using mass spectrometry and imaging. Notably, enable optical control of apoptosis, which is not observed with long-chain variants. Additionally, they function as photoswitchable substrates for sphingomyelin synthase 2 (SMS2), exhibiting inverted light-dependence compared to their extended analogs.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acschembio.0c00823 | DOI Listing |
Publication Analysis
Top Keywords
enable optical
8
optical control
8
control apoptosis
8
short photoswitchable
4
photoswitchable ceramides
4
ceramides enable
4
apoptosis report
4
report short
4
short ceramide
4
ceramide analogs
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!