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A mouth rinse based on a tea solution of Salvia officinalis for oral discomfort in palliative cancer care: a randomized controlled trial. | LitMetric

AI Article Synopsis

  • The study explores the effectiveness of a Salvia officinalis (SO) mouth rinse compared to a normal saline (NS) rinse for improving oral health in palliative care patients undergoing cancer treatment.
  • Conducted as a block-randomized controlled trial, data was collected from 88 adult patients before and after a 4-day treatment, measuring oral symptoms through various rating scales.
  • While both mouth rinses improved overall oral health, the SO rinse showed a greater improvement in dry mouth symptoms specifically, although no overall significant difference was found between the two treatments.

Article Abstract

Background: Few clinical studies evaluate interventions to reduce oral discomfort among patients in palliative care.

Aim: This study examines the efficacy of a Salvia officinalis (SO) based herbal mouth rinse compared to conventional normal saline (NS) in order to improve oral health.

Design: A block-randomized controlled trial. Data were collected before and after a 4-day intervention with either SO (n=44) or NS (n=44). Numerical rating scales (NRS, 0-10) and 12 items from the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-Oral Health 17 (EORTC QLQ-OH17) measured patient-reported oral symptoms. An oral examination was performed before and after the intervention.

Setting/participants: This study included adult patients with late-stage cancer in an inpatient hospice unit.

Results: Of the 88 patients included (mean age=63.9 years, SD=10.6), 73 (83%) completed the study. At baseline, 78% reported dry mouth on the EORTC QLQ-OH17, and 80% rated dry mouth ≥4 on the NRS. Total oral health scores based on the 12 EORTC QLQ-OH17 items improved similarly in both groups (p<0.001). However, dry mouth ratings on both the EORTC QLQ-OH17 (p=0.036) and NRS (p=0.045) improved more in the SO group than in the NS group. Plaque on the teeth improved in both the SO (p=0.008) and NS (p=0.018) groups, but plaque on the tongue and erythema only improved with NS.

Conclusions: This study did not detect an overall significant difference between SO and NS. Both mouth rinses improved oral health parameters, indicating that systematic assessment and oral care may reduce oral discomfort.

Trial Registration: NCT02067572.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295113PMC
http://dx.doi.org/10.1007/s00520-021-06021-2DOI Listing

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