Hypervolemia is a condition with an excess of total body water and when sodium (Na) intake exceeds output. It can have different causes, such as hypervolemic hyponatremia (often associated with decreased, effective circulating blood volume), hypervolemia associated with metabolic alkalosis, and end-stage renal disease. The degree of hypervolemia in critically ill children is a risk factor for mortality, regardless of disease severity. A child (under 18 years of age) with hypervolemia requires fluid removal and fluid restriction. Diuretics are able to increase or maintain urine output and thus improve fluid and nutrition management, but their benefit in preventing or treating acute kidney injury is questionable.
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http://dx.doi.org/10.1055/s-0040-1714703 | DOI Listing |
J Feline Med Surg
December 2024
School of Veterinary Science, The University of Queensland, Gatton, QLD, Australia.
Objectives: The primary objective of this investigation was to ultrasonographically evaluate the caudal vena cava to aorta (CVC:Ao) ratio in healthy, conscious cats and to generate reference intervals. A secondary objective was to identify the site of examination with the least intra- and inter-observer variability. This investigation was undertaken to assess whether the CVC:Ao ratio holds promise as a technique to assess intravascular volume responsiveness in cats.
View Article and Find Full Text PDFEinstein (Sao Paulo)
December 2024
Internal Medicine Department, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, SP, Brazil.
Objective: The efficacy of icodextrin versus glucose patients undergoing peritoneal dialysis remains unclear. The study was designed to compare the effects of once-daily long-dwell icodextrin versus glucose on markers of hypervolemia and survival among patients with kidney failure undergoing an unplanned initiation of automated peritoneal dialysis.
Methods: This was a randomized, non-blinded, and prospective controlled study.
J Clin Med
September 2024
Department of Cardiology and Internal Diseases, Military Institute of Medicine, National Research Institute, 04-141 Warsaw, Poland.
The main cause of hospitalization in patients with heart failure is hypervolemia. Therefore, the primary treatment strategy involves diuretic therapy using intravenous loop diuretics to achieve decongestion and euvolemia. Some patients with acutely decompensated heart failure (ADHF) do not respond well to diuretic treatment, which may be due to diuretic resistance (DR).
View Article and Find Full Text PDFEClinicalMedicine
October 2024
Klinik für Thorax- und Kardiovaskuläre Chirurgie, Westdeutsches Herz- und Gefäßzentrum Essen, Universität Duisburg-Essen, Germany.
Background: Cardiac surgery invariably triggers acute kidney stress causing adverse renal outcomes. The AKITA study evaluated the efficacy and safety of RMC-035, a novel analogue of alpha-1-microglobulin, for reducing cardiac surgery-associated kidney injury.
Methods: In this randomised double-blind placebo-controlled phase 2a study, we randomly assigned (1:1) adult hospitalised patients undergoing open-chest cardiac surgery at high risk for acute kidney injury (AKI) at 21 sites in North America and Europe to receive either RMC-035 (1.
Cureus
August 2024
Medicine, Dr. D.Y. Patil Medical College, Hospital and Research Centre, Dr. D.Y. Patil Vidyapeeth (Deemed to be University) Pimpri, Pune, IND.
Aim The aim of this study is to analyze the demographic distribution (age and gender distribution), presenting symptoms, and evaluate the underlying etiology of hyponatremia among the study population. The presence of comorbidities and the volume status (hypovolemia, euvolemia, or hypervolemia) of elderly hyponatremic patients with varying severity of hyponatremia were assessed. Methods This cross-sectional, observational study was conducted in Dr.
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