Detection and Elimination of Signal Errors Due to Unintentional Movements in Biomedical Magnetic Induction Tomography Spectroscopy (MITS).

In biomedical MITS, slight unintentional movements of the patient during measurement can contaminate the aimed images to a great extent. This study deals with measurement optimization in biomedical MITS through the detection of these unpredictable movements during measurement and the elimination of the resulting movement artefacts in the images to be reconstructed after measurement. The proposed detection and elimination (D&E) methodology requires marking the surface of the object under investigation with specific electromagnetically perturbing markers during multi-frame measurements. In addition to the active marker concept already published, a new much simpler passive marker concept is presented. Besides the biological signal caused by the object, the markers will perturb the primary magnetic field inducing their own signals. The markers' signals will be used for the detection of any unwanted object movements and the signal frames corrupted thereby. The corrupted signal frames will be then excluded from image reconstruction in order to prevent any movement artefacts from being imaged with the object. In order to assess the feasibility of the developed D&E technique, different experiments followed by image reconstruction and quantitative analysis were performed. Hereof, target movements were provoked during multifrequency, multiframe measurements in the β-dispersion frequency range on a saline phantom of physiological conductivity. The phantom was marked during measurement with either a small single-turn coil, an active marker, or a small soft-ferrite plate, a passive marker. After measurement, the erroneous phantom signals were corrected according to the suggested D&E strategy, and images of the phantom before and after correction were reconstructed. The corrected signals and images were then compared to the erroneous ones on the one hand, and to other true ones gained from reference measurements wherein no target movements were provoked on the other hand. The obtained qualitative and quantitative measurement and image reconstruction results showed that the erroneous phantom signals could be accurately corrected, and the movement artefacts could be totally eliminated, verifying the applicability of the novel D&E technique in measurement optimization in biomedical MITS and supporting the proposed aspects.