The current 5-year survival rate for cancer in infants is greater than 75% in developed countries. However, survivors of neonatal malignancies have an increased risk of late effects from their tumor or its treatment, which may lead to long-term morbidity and/or early mortality. This article reviews surgical approaches and chemotherapeutic agents commonly used in neonatal malignancies and their associated late effects. It also reviews the increased risk for late effects associated with radiation at a young age and hematopoietic stem cell transplantation at a young age.. It highlights the importance of survivor-specific multidisciplinary care in the long-term management of neonatal cancer survivors.
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http://dx.doi.org/10.1016/j.clp.2020.11.009 | DOI Listing |
Int Psychogeriatr
March 2025
Social Policy and Advocacy, Department of Psychiatry, Dalhousie University, Room 6507 Abbie Lane Building, 5909 Veteran's Memorial Lane, Halifax, Nova Scotia B3H 1H9, Canada.
Objectives: Enhanced cognitive behavioural therapy for older adults (CBT-OA) modifies standard CBT to better address the needs of older adults, considering age-related impacts on learning. This study evaluated the effectiveness of Cassidy's manualized CBT-OA protocol (Cassidy, 2016a, 2016b) for late-life depression or anxiety in a larger sample at a different center.
Design: This retrospective observational study used a within-subject pre-/post-data design to evaluate the CBT-OA group for seniors with depression or anxiety.
Int Psychogeriatr
March 2025
Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Toronto Dementia Research Alliance, University of Toronto, Toronto, Ontario, Canada.
Objectives: The number of older adults with schizophrenia ("late-life schizophrenia" (LLS)) is growing with the aging of the general population. Cognitive impairment in adults with LLS predicts functioning. Cognitive remediation (CR) improves cognition in schizophrenia, however literature in LLS is sparse.
View Article and Find Full Text PDFInt J Biol Macromol
March 2025
College of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming, Yunnan, China. Electronic address:
Liquid-liquid phase separation (LLPS) of nuclear pore complex (NPC) with nuclear transport proteins (NTPs) via intrinsically disordered regions (IDRs) plays a crucial role in the nucleocytoplasmic transport. The development of efficient targeted delivery systems based on LLPS has attracted widespread attention. Here, we developed nanocarriers of casein peptides, a natural intrinsically disordered proteins (IDPs), modified with fatty acids of different alkyl chains (C10-C18) and decorated by shellac for highly effective drug delivery and cancer therapy.
View Article and Find Full Text PDFMar Environ Res
March 2025
College of Fisheries, Guangdong Ocean University, Zhanjiang, China. Electronic address:
Semi-enclosed gulfs play important roles in global marine ecosystems, but they are vulnerable to anthropogenic disturbance and the effects of climate change. Beibu Gulf, the largest semi-enclosed gulf in China, is characterized by complex oceanographical conditions and high fish diversity, and it is an important fishing and spawning ground for many fish species. However, little is known about where these fishes spawn.
View Article and Find Full Text PDFLasers Med Sci
March 2025
Beijing Anzhen Nanchong Hospital of Capital Medical University &Amp, Nanchong Central Hospital, Nanchong, China.
This study compares the surgical and functional outcomes of photoselective vaporization of the prostate (PVP), anatomical PVP (aPVP), and Greenlight laser enucleation of the prostate (GreenLEP) in the treatment of benign prostatic hyperplasia (BPH). A comprehensive search was conducted in February 2024 across PubMed, the Cochrane Library, and EMBASE databases, following PRISMA guidelines and registered with PROSPERO (CRD42024518321). Thirteen studies were included, with 11 analyzed in the meta-analysis.
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