AI Article Synopsis
- ACE is a zinc-dependent enzyme that regulates blood pressure by converting angiotensin I to angiotensin II, and it has other physiological effects beyond just blood pressure control.
- The overexpression of ACE affects the immune system by enhancing the function of macrophages and neutrophils, leading to improved antitumor and antimicrobial responses.
- Understanding ACE's role in immune cell activity may offer potential therapeutic strategies for treating infections and cancers.
Article Abstract
Angiotensin-converting enzyme (ACE) is a zinc-dependent dicarboxypeptidase with two catalytic components, which has an important role in regulating blood pressure by converting angiotensin I to angiotensin II. ACE breaks down other peptides besides angiotensin I and has a variety of physiological effects together with renal growth and reproduction in men. ACE also acts on innate and acquired immune systems by affecting macrophage and neutrophil function, and these outcomes are exacerbated due to the overexpression of ACE. Overexpression of ACE in macrophages imposes antitumor and antimicrobial response, and it enhances the ability of neutrophils to produced super peroxide that has a bactericidal effect. ACE is also known to contribute to the expression of Major Histocompatibility Complex (MHC) class I and MHC class II peptides through enzymatic alterations of these peptides. Apprehending the expression of ACE and its effects on myeloid cell (myelogenous cells) activity can be promising in therapeutic interventions, including treatment of infection and malignancy.
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| http://dx.doi.org/10.2174/1871530321666210212144511 | DOI Listing |
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