AI Article Synopsis
- Major depressive disorder (MDD) is a prevalent psychiatric condition with significant economic impacts, caused by a combination of social, psychological, and biological factors.
- There is no single explanation for its development; instead, it involves a complex interplay of genetics, neurobiology, and brain imaging.
- Current treatment options include medications, therapy, and new neuromodulation technologies, with recent advancements leading to the development of new antidepressants that are now being used clinically.
Article Abstract
Major depressive disorder (MDD), also referred to as depression, is one of the most common psychiatric disorders with a high economic burden. The etiology of depression is still not clear, but it is generally believed that MDD is a multifactorial disease caused by the interaction of social, psychological, and biological aspects. Therefore, there is no exact pathological theory that can independently explain its pathogenesis, involving genetics, neurobiology, and neuroimaging. At present, there are many treatment measures for patients with depression, including drug therapy, psychotherapy, and neuromodulation technology. In recent years, great progress has been made in the development of new antidepressants, some of which have been applied in the clinic. This article mainly reviews the research progress, pathogenesis, and treatment of MDD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8192601 | PMC |
| http://dx.doi.org/10.1007/s12264-021-00638-3 | DOI Listing |
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