Safety assessment of road sections and networks have historically relied on police-reported crash data. These data have several noteworthy and significant shortcomings, including under-reporting, subjectivism, post hoc assessment of crash causes and contributing factors, limited behavioural information, and omitted potential important crash-related factors resulting in an omitted variable bias. Moreover, crashes are relatively rare events and require long observation periods to justify expenditures. The rarity of crashes leads to a moral dilemma-we must wait for sufficient crashes to accrue at a site-some involving injuries and even death-to then justify improvements to prevent crashes. The more quickly the profession can end its reliance on crashes to assess road safety, the better. Surrogate safety assessment methodologies, in contrast, are proactive in design, do not rely on crashes, and require shorter observation timeframes in which to formulate reliable safety assessments. Although surrogate safety assessment methodologies have been developed and assessed over the past 50 years, an overarching and unifying framework does not exist to date. A unifying framework will help to contextualize the role of various methodological developments and begin a productive discussion in the literature about how the various pieces do or should fit together to understand road user risk better. This paper aims to fill this gap by thoroughly mapping traffic conflicts and surrogate safety methodologies. A total of 549 studies were meticulously reviewed to achieve this aim of developing a unifying framework. The resulting framework provides a consolidated and up-to-date summary of surrogate safety assessment methodologies and conflict measures and metrics. Further work is needed to advance surrogate safety methodologies. Critical research needs to include identifying a comprehensive and reliable set of surrogate measures for risk assessment, establishing rigorous relationships between conflicts and crashes, developing ways to capture road user behaviours into surrogate-based safety assessment, and integrating crash severity measures into risk estimation.
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http://dx.doi.org/10.1016/j.aap.2021.106016 | DOI Listing |
Curr Opin Organ Transplant
January 2025
Department of Kinesiology and Health Sciences.
Purpose Of Review: Patients that present with a physical frail phenotype have a higher risk of poor kidney transplant outcomes and are therefore less likely to be wait listed for a transplant. The physical frailty phonotype is more prevalent in older adults >65years with chronic and end stage kidney disease, thus partly contributing to inequitable access to transplant. Frailty can potentially be reversed by prehabilitation.
View Article and Find Full Text PDFInt J Parasitol Drugs Drug Resist
January 2025
Department of Infectious Diseases, Unit of Foodborne and Neglected Parasitic Diseases, Istituto Superiore di Sanità, viale Regina Elena 299, Rome, Italy. Electronic address:
Giardia duodenalis is a widespread intestinal protozoan that affects mammals, including humans. Symptoms can range from being subclinical to causing severe abdominal pain and diarrhoea. Giardiasis often requires repeated treatment with synthetic drugs like metronidazole.
View Article and Find Full Text PDFAm J Emerg Med
January 2025
Departments of Emergency Medicine and Critical Care Medicine, Stanford Health Care, 900 Welch Road, Palo Alto, CA 94304, USA.
Background: Critically ill ED patients on life support may undergo transition to comfort care as decided by the surrogate decision maker. When several hours are needed for loved ones to arrive and say farewell before initiating comfort care ("delayed comfort care"), these patients require prolonged ED stays or costly intensive care unit (ICU) admissions.
Methods: A novel ED observation unit (EDOU)-based delayed comfort care pathway for ED patients on invasive mechanical ventilation and/or vasopressors was created in 2013 at Stanford Hospital.
Sci Total Environ
February 2025
College of Water Resources and Civil Engineering, China Agricultural University, Beijing 100083, China.
Groundwater is one of the main sources of drinking water, thus, human enteric viruses in groundwater could pose safety risks. Many enteric viruses enter drinking water sources through irrigation or recharge of contaminated water. It is therefore advised to test the potential transport risk with harmless surrogates before wastewater or recycled water is used for irrigation or groundwater recharge.
View Article and Find Full Text PDFNat Commun
January 2025
Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Neutralizing antibody titer has been a surrogate endpoint for guiding COVID-19 vaccine approval and use, although the pandemic's evolution and the introduction of variant-adapted vaccine boosters raise questions as to this surrogate's contemporary performance. For 985 recipients of an mRNA second bivalent or monovalent booster containing various Spike inserts [Prototype (Ancestral), Beta, Delta, and/or Omicron BA.1 or BA.
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