Store-operated Orai channels are a primary mechanism for mobilizing Ca signals in both non-excitable cells and excitable cells. The structure of the open channel, vital for understanding the mechanism of channel opening, is incompletely understood. We highlight a new study that unveils the structure of a constitutively active Orai mutant and takes us closer towards understanding the molecular basis of Orai channel activation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202095 | PMC |
| http://dx.doi.org/10.1016/j.ceca.2021.102366 | DOI Listing |
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