Purpose: Improved early diagnosis and determination of aggressiveness of prostate cancer (PC) is important to select suitable treatment options and to decrease over-treatment. The conventional marker is total prostate specific antigen (PSA) levels in blood, but lacks specificity and ability to accurately discriminate indolent from aggressive disease.
Experimental Design: In this study, we sought to identify a serum biomarker signature associated with metastatic PC. We measured 157 analytes in 363 serum samples from healthy subjects, patients with non-metastatic PC and patients with metastatic PC, using a recombinant antibody microarray.
Results: A signature consisting of 69 proteins differentiating metastatic PC patients from healthy controls was identified.
Conclusions And Clinical Relevance: The clinical value of this biomarker signature requires validation in larger independent patient cohorts before providing a new prospect for detection of metastatic PC.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9310707 | PMC |
| http://dx.doi.org/10.1002/prca.202000025 | DOI Listing |
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