AI Article Synopsis
- The study aimed to determine if chemoradiotherapy enhances survival in patients with advanced nasopharyngeal carcinoma (NPC) compared to radiotherapy alone.
- Data were analyzed from 496 patients, with those receiving chemoradiotherapy showing better overall survival rates before a matching analysis, but no significant difference in survival rates after adjusting for other factors.
- The final conclusion indicated that both treatment options have comparable overall survival and cancer-specific survival for patients with stage T3-4N0M0 NPC.
Article Abstract
Purpose: To identify whether chemoradiotherapy improves survival in patients with stage T3-4N0M0 nasopharyngeal carcinoma (NPC).
Materials And Methods: The data of patients with stage T3-4N0M0 NPC were extracted from the Surveillance, Epidemiology, and End Results database between 2004 and 2016. The patients were divided into radiotherapy and chemoradiotherapy groups. Overall survival (OS) and cancer-specific survival (CSS) were assessed using the Kaplan-Meier method and propensity score matching (PSM) analyses.
Results: We examined 496 patients: 88 who received radiotherapy and 408 who received chemoradiotherapy. Before PSM, chemoradiotherapy was associated with a better 5-year OS (52.58% vs. 38.13%; P = .005) and similar CSS (63.62% vs. 59.26%; P = .196) compared to those associated with radiotherapy. However, chemoradiotherapy was not an independent prognostic factor for OS [hazard ratio (HR)=0.95, 95% confidence interval (CI): 0.68-1.32; P = .760] or CSS (HR = 1.02, 95% CI: 0.66-1.56; P = .935). After PSM, similar OS (45.15% vs. 42.78%; P = .626) and CSS (58.22% vs. 60.37%; P = .730) were found between the radiotherapy and chemoradiotherapy groups.
Conclusion: Radiotherapy and chemoradiotherapy are associated with similar OS and CSS in patients with stage T3-4N0M0 NPC.
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| http://dx.doi.org/10.1111/coa.13738 | DOI Listing |
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