AI Article Synopsis
- Toxic amyloid-β (Aβ) proteins are key players in the development of Alzheimer's disease (AD), with higher levels of toxic Aβ42 conformers found in patients with AD and mild cognitive impairment.
- The study aimed to assess the levels of toxic Aβ42 and its relation to the progression of AD by comparing different patient groups and healthy controls.
- Findings indicated that while the overall toxic Aβ level wasn’t significantly different among groups, its increased ratio to Aβ42 in AD patients correlated with higher levels of tau protein and lower cognitive function, suggesting a link between toxic Aβ and neuronal impairment in AD.
Article Abstract
Background: Toxic amyloid-β protein (Aβ) conformers play an important role in the progression of Alzheimer's disease (AD). The ratio of toxic conformer to total Aβ42 in cerebrospinal fluid (CSF) was significantly high in AD and mild cognitive impairment (MCI) due to AD using an enzyme-linked immunosorbent assay kit with a 24B3 antibody.
Objective: We compared the toxic Aβ42, conformer at different stages of AD to identify its contribution to AD pathogenesis.
Methods: We compared 5 patients with preclinical AD, 11 patients with MCI due to AD, 21 patients with AD, and 5 healthy controls to measure CSF levels of total Aβ42, total tau, tau phosphorylated at threonine 181 (p-tau), and toxic Aβ conformers. All were classified using the Clinical Dementia Rating. Cognitive function was assessed using the Japanese version of the Mini-Mental State Examination (MMSE-J).
Results: Toxic Aβ conformer level was insignificant between groups, but its ratio to Aβ42 was significantly higher in AD than in preclinical AD (p < 0.05). Toxic Aβ42 conformer correlated positively with p-tau (r = 0.67, p < 0.01) and p-tau correlated negatively with MMSE-J (r = -0.38, p < 0.05).
Conclusion: Toxic Aβ conformer triggers tau accumulation leading to neuronal impairment in AD pathogenesis.
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| http://dx.doi.org/10.3233/JAD-201407 | DOI Listing |
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