AI Article Synopsis
- Clopidogrel and proton pump inhibitors (PPIs) are commonly prescribed medications in Denmark, with increasing usage rates, especially among individuals with diabetes.
- A study used the Danish Register of Medicinal Product Statistics to analyze prescription patterns and found a notable rise in the use of both drugs over five years, with significantly higher prevalence in diabetics.
- The findings highlight the importance of considering drug-drug and drug-gene interactions in medical decisions, especially for antiplatelet therapy like clopidogrel among vulnerable populations like the elderly and those with diabetes.
Article Abstract
Background: Clopidogrel and proton pump inhibitors (PPIs) are among the most used drugs in Denmark for which there exists pharmacogenomics (PGx)-based dosing guidelines and FDA annotations. In this study, we further scrutinized the use of clopidogrel and PPIs when prescriptions were redeemed from Danish Pharmacies alone or in combination in the Danish population and among persons with diabetes in Denmark. The focus deals with the potential of applying PGx-guided antiplatelet therapy taking both drug-drug interactions (DDI) and drug-gene interactions (DGI) into account.
Methods: The Danish Register of Medicinal Product Statistics was the source to retrieve consumption data.
Results: The consumption of PPIs and clopidogrel in terms of prevalence (users/1000 inhabitants) increased over a five-year period by 6.3% to 103.1 (PPIs) and by 41.7% to 22.1 (clopidogrel), respectively. The prevalence of the use of clopidogrel and PPIs in persons with diabetes are 3.8 and 2.1-2.8 times higher compared to the general population. When redeemed in combination, the prevalence increased to 4.7. The most used combination was clopidogrel and pantoprazole.
Conclusions: The use of clopidogrel and PPIs either alone or in combination is quite widespread, in particular among the elderly and persons with diabetes. This further supports the emerging need of accessing and accounting for not only DDI but also for applying PGx-guided drug therapy in clinical decision making for antiplatelet therapy with clopidogrel having a particular focus on persons with diabetes and the elderly.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916548 | PMC |
| http://dx.doi.org/10.3390/metabo11020096 | DOI Listing |
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