Background: Adolescent peers' influence on tobacco smoking is a dynamic process affected by close friends and other network peers. Although research has examined the influence of immediate friends on smoking behavior (i.e., by cohesion exposure), the influence of all peers according to closeness (i.e., proximity exposure) remains unknown. This study introduces proximity exposure as a potential driver of peer influence.
Methods: Using the Teenage Friends and Lifestyle Study dataset, we examined 160 adolescents followed for 3 years and assessed their friendship ties and health behavior. Proximity exposure was calculated as the proportion of an individual's network peers who smoked, considering their distance from the individual. Path analysis was conducted with cross-lagged models testing the effect of proximity exposure on smoking frequency over time.
Results: Among nonsmokers without cohesion exposure (n = 80), proximity exposure at year 1 was significantly associated with smoking initiation by year 3. Path analysis (n = 160) indicated that smoking at year 1 predicted cohesion exposure by year 3. When proximity exposure was included, the effect of smoking on cohesion exposure was lost. Early smoking predicted future proximity exposure. However, the predictive value of early proximity toward future smoking was stronger.
Conclusion: These results suggest that proximity exposure can predict smoking even among nonsmokers without direct ties to friends who smoke. In support of a peer selection hypothesis, early smoking predicted friendship formation with smokers through cohesion. Conversely, in support of a peer influence hypothesis, proximity exposure predicted smoking. Researchers may consider developing interventions that decrease proximity exposure among adolescents.
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http://dx.doi.org/10.1016/j.addbeh.2021.106853 | DOI Listing |
ACS Chem Biol
January 2025
Department of Chemical Biology, Max Planck Institute for Medical Research, Jahnstraße 29, 69120 Heidelberg, Germany.
Protein interactions play a crucial role in regulating cellular mechanisms, highlighting the need for effective methods to control these processes. In this regard, chemical inducers of proximity (CIPs) offer a promising approach to precisely manipulate protein-protein interactions in live cells and . In this study, we introduce pMandi, a photocaged version of the plant hormone-based CIP mandipropamid (Mandi), which allows the use of light as an external trigger to induce protein proximity in live mammalian cells.
View Article and Find Full Text PDFPeptides play critical roles in cellular functions such as signaling and immune regulation, and peptide-based biotherapeutics show great promise for treating various diseases. Among these, cell-penetrating peptides (CPPs) are particularly valuable for drug delivery due to their ability to cross cell membranes. However, the mechanisms underlying CPP-mediated transport, especially across the blood-brain barrier (BBB), remain poorly understood.
View Article and Find Full Text PDFJ Allergy Clin Immunol
January 2025
Departments of Animal Science, Integrative Biology and Physiology, University of Minnesota,St. Paul, MN, 55108. Electronic address:
Background: Environmental allergens induce the release of danger signals from the airway epithelium that trigger type 2 immune responses and promote airway inflammation.
Objective: To investigate the role of allergen-stimulated P2Y receptor activation in regulating ATP, IL-33 and DNA release by human bronchial epithelial (hBE) cells and mouse airways.
Methods: hBE cells were exposed to Alternaria alternata extract and secretion of ATP, IL-33 and DNA were studied in vitro.
Int J Environ Res Public Health
January 2025
Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.
The rapid growth of unconventional natural gas development (UNGD), also known as hydraulic fracturing, has raised concerns of potential exposures to hazardous chemicals. Few studies have examined the risk of childhood cancer from exposure to UNGD. A case-control study included 498 children diagnosed with leukemia, lymphoma, central nervous system neoplasms, and malignant bone tumors during the period 2010-2019 identified through the Pennsylvania Cancer Registry.
View Article and Find Full Text PDFInt J Environ Res Public Health
December 2024
Department of Physical Education and Sport Science, University of Thessaly, Karies, 42100 Trikala, Greece.
Background: Migrant construction workers involved in building infrastructure for mega-sporting events face elevated risks of illness and death. However, specific health outcomes for these workers have not been systematically reviewed, limiting opportunities to identify and address their challenges.
Methods: This study systematically reviewed health outcomes among migrant construction workers involved in mega-sporting events.
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