Case: A 47-year-old healthy man underwent cervical disc arthroplasty (CDA) for a C6 radiculopathy. Two-week radiographs showed a well-positioned implant. At the 6-week postoperative visit, the inferior portion of the implant had displaced ventrally, with C6 anterior vertebral body collapse. The next day, the implant was removed and converted to a C5/6 anterior cervical discectomy and fusion. Bone biopsy was unremarkable.
Conclusions: This is the first reported case of early catastrophic failure of a well-positioned CDA in a healthy patient with good bone quality. Possible contributing mechanisms include hypermobility and anterior bone loss, factors previously associated with CDA.
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http://dx.doi.org/10.2106/JBJS.CC.20.00185 | DOI Listing |
Data Brief
December 2024
Instituto de Ciencias de la Atmósfera y Cambio Climático, Universidad Nacional Autónoma de México, Ciudad de México 04510, Mexico.
Tropical cyclones (TCs) are catastrophic phenomena that constantly threaten populations settled in the tropics. Their direct effects (strong winds, storm surges, and intense precipitation) are confined near the TC center. On the other hand, the indirect effects are due to extreme rainfall events associated with rainbands distant from the TC center.
View Article and Find Full Text PDFMed J Armed Forces India
December 2024
Classified Specialist (Radiology), Command Hospital (Northern Command), Udhampur, India.
Puerperal inversion of uterus is a catastrophic and a rare complication, which occurs during the third stage of labour. It can lead to severe haemorrhage and shock which results in maternal morbidity and mortality. When diagnosed correctly, early cases can be managed by manual reposition, but neglected and late cases need surgery.
View Article and Find Full Text PDFNucleic Acids Res
December 2024
Department of Biology, Saint Louis University, 3507 Laclede Ave, Saint Louis, MO 63103, USA.
Moderating the pool of active ribosomal subunits is critical for maintaining global translation rates. A factor crucial for modulating the 60S ribosomal subunit is eukaryotic translation initiation factor-6 (eIF6). Release of eIF6 from the 60S subunit is essential to permit 60S interactions with the 40S subunit.
View Article and Find Full Text PDFFront Pediatr
December 2024
Pediatric Intensive Care Unit, The Second Hospital of Lanzhou University, Lanzhou, China.
Background: Antiphospholipid syndrome (APS) is an autoimmune disease characterized by recurrent vascular thrombotic events. Catastrophic APS (CAPS), which can result in multiple organ failure and even death, is the most severe manifestation of APS. Herein, we report the case of a pediatric patient with CAPS, including the clinical course, diagnosis, and treatment, with the goal of expanding the literature on this condition, as reports of CAPS in pediatric patients are rare.
View Article and Find Full Text PDFBlood
December 2024
Dana-Farber Cancer Institute, BOSTON, Massachusetts, United States.
Allogeneic hematopoietic stem-cell transplantation (HCT) is one of the principal curative approaches in the treatment of acute myeloid leukemia (AML); however, relapse post-transplantation remains a catastrophic event with poor prognosis. The incidence of relapse has remained unchanged over the last three decades despite an evolving understanding of the immunobiology of the graft-versus leukemia effect and the immune escape mechanisms that lead to post-HCT relapse. The approach to post-transplant relapse is highly individualized and is dictated both by disease biology and genomics as well as the patient's clinical status at the time of relapse and the interval between relapse and transplantation.
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