AI Article Synopsis
- Human pluripotent stem cells (hPSCs) can differentiate into various cell types, including pericytes, which support blood vessel formation and have good growth abilities in culture.
- In tests on mice with ischemic hind limbs, injecting hPSC-derived pericytes promoted new blood vessel growth and reduced muscle loss.
- The document presents a method for efficiently producing large quantities of pericytes from hPSC-embryoid bodies.
Article Abstract
Human pluripotent stem cells (hPSCs), either embryonic or induced, offer a plentiful platform for derivation of multiple cell types. Pericytes, generated from hPSCs, are multipotent precursors with vasculogenic features that exhibit high proliferation capability in long-term cultures. Administration of hPSC-pericytes into ischemic murine hind limb is associated with therapeutic angiogenesis and attenuation of muscle wasting. Here, we describe the protocol for derivation of large numbers of pericytes from spontaneously differentiating hPSC-embryoid bodies.
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| http://dx.doi.org/10.1007/978-1-0716-1056-5_8 | DOI Listing |
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