AI Article Synopsis
- The study assessed the effectiveness of ΔPb-CATH4, a cathelicidin from Python bivittatus, on wounds infected with Staphylococcus aureus in mice, showing similar outcomes to traditional antibiotics.
- ΔPb-CATH4 demonstrated resistance to bacterial proteases but was affected by porcine trypsin.
- The findings indicated that ΔPb-CATH4 aids in wound healing by reducing inflammation and enhancing immune cell migration, making it a potential treatment for infections, including those caused by antibiotic-resistant bacteria.
Article Abstract
The effects of ΔPb-CATH4, a cathelicidin derived from Python bivittatus, were evaluated against Staphylococcus aureus-infected wounds in mice. These effects were comparable to those of classical antibiotics. ΔPb-CATH4 was resistant to bacterial protease but not to porcine trypsin. A reduction in the level of inflammatory cytokines and an increase in the migration of immune cells was observed in vitro. Thus, ΔPb-CATH4 can promote wound healing by controlling infections including those caused by multidrug-resistant bacteria via its immunomodulatory effects.
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| http://dx.doi.org/10.1007/s00726-021-02948-2 | DOI Listing |
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