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Perioperative analgesic effects of a modified supratemporal retrobulbar block in dogs undergoing corneal and endocular surgery.
J Small Anim Pract
January 2025
Department of Veterinary Science, University of Turin, Grugliasco, Italy.
Objectives: To evaluate the perioperative efficacy of a modified supratemporal retrobulbar block in dogs undergoing ocular surgery.
Materials And Methods: In this prospective randomized clinical trial, dogs were premedicated with dexmedetomidine (1 mcg/kg im) and methadone (0.1 mg/kg im), induced with propofol to effect and maintained with isoflurane (FE'Iso 1.
Blind supratemporal retrobulbar block in cats: a feasibility cadaveric study and its efficacy in a group of subjects undergoing corneal or intraocular surgery.
Front Vet Sci
November 2024
Department of Veterinary Science, University of Turin, Turin, Italy.
Article Synopsis
- The study investigates the supratemporal retrobulbar block as an anesthetic technique in cats, addressing its effectiveness and injection methods.
- A modified injection of a specific mixture was performed on cadavers, showing a high success rate in contrast agent spread and good distribution around the optic nerve.
- In a clinical setting with 12 cats, the retrobulbar group experienced fewer anesthetist interventions compared to the control group, indicating a potential advantage of the supratemporal approach for surgeries.
Gut microbial metabolism of bile acids modifies the effect of Mediterranean diet interventions on cardiometabolic risk in a randomized controlled trial.
Gut Microbes
November 2024
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Bile acids (BAs) undergo extensive microbial metabolism in the gut and exert hormone-like functions on physiological processes underlying metabolic risk. However, the extent to which gut BA profiles predict cardiometabolic risk and explain individual responses to dietary interventions in humans is still unclear. In the DIRECT-PLUS Trial, we conducted a multi-omics analysis of 284 participants randomized into three groups: healthy dietary guidelines and two Mediterranean diet (MedDiet) groups.
View Article and Find Full Text PDFUltrasound-assisted Thoracic Intervertebral Foramen Block. A Cadaveric Study.
Pain Physician
May 2024
Department of Life, Health and Environmental Sciences, University of L'Aquila, Piazzale Salvatore Tommasi, Coppito, Italy.
Background: A thoracic paravertebral block can be a useful opioid-sparing technique for controlling postoperative pain after thoracic and visceral abdominal surgery.
Objectives: Our aim was to assess dye spread into the ventral branch, connecting branch, sympathetic trunk, thoracic paravertebral space, and epidural space after performing a modified ultrasound-assisted thoracic paravertebral block via the intervertebral foramen.
Study Design: This was a nonrandomized cadaveric study.
VWF-ADAMTS13 axis dysfunction in children with sickle cell disease treated with hydroxycarbamide vs blood transfusion.
Blood Adv
November 2023
Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.
Previous studies have reported elevated von Willebrand factor (VWF) levels in patients with sickle cell disease (SCD) and demonstrated a key role for the VWF-ADAMTS13 axis in the pathobiology of SCD vaso-occlusion. Although blood transfusion is the gold standard for stroke prevention in SCD, the biological mechanisms underpinning its improved efficacy compared with hydroxycarbamide are not fully understood. We hypothesized that the improved efficacy of blood transfusion might relate to differences in VWF-ADAMTS13 axis dysfunction.
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