Introduction: Intestinal microbiota is arising as a new element in the physiopathology of cardiovascular diseases. A healthy microbiota includes a balanced representation of bacteria with health promotion functions (symbiotes). The aim of this study is to analyse the relationship between intestinal microbiota composition and arterial stiffness.
Methods And Analysis: An observational case-control study will be developed. Cases will be defined by the presence of at least one of the following: carotid-femoral pulse wave velocity (cf-PWV), Cardio-Ankle Vascular Index (CAVI), brachial ankle pulse wave velocity (ba or ba-PWV) above the 90 percentile, for age and sex, of the reference population. Controls will be selected from the same population as cases. The study will be developed in Primary Healthcare Centres. We will select 500 subjects (250 cases and 250 controls), between 45 and 74 years of age. Cases will be selected from a database that combines data from EVA study (Spain) and Guimarães/Vizela study (Portugal).
Measurements: cf-PWV will be measured using the SphygmoCor system, CAVI, ba-PWV and Ankle-Brachial Index will be determined using VaSera device. Gut microbiome composition in faecal samples will be determined by 16S ribosomal RNA sequencing. Lifestyle will be assessed by food frequency questionnaire, adherence to the Mediterranean diet and IPAQ (International Physical Activity Questionnaire). Body composition will be evaluated by bioimpedance.
Ethics And Dissemination: The study has been approved by 'Committee of ethics of research with medicines of the health area of Salamanca' on 14 December 2018 (cod. 2018-11-136) and the 'Ethics committee for health of Guimaraes' (Portugal) on 15 October 2019 (ref: 67/2019). All study participants will sign an informed consent form agreeing to participate in the study, in compliance with the Declaration of Helsinki and the WHO standards for observational studies. The results of this study will allow a better description of gut microbiota in patients with arterial stiffness.
Trial Registration Details: ClinicalTrials.gov, identifier NCT03900338.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880115 | PMC |
| http://dx.doi.org/10.1136/bmjopen-2020-038933 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Insights into morphology of the 'columnar epithelium' within the female reproductive system of brachyuran crabs.
Arthropod Struct Dev
January 2025
Zoological Museum, University of Kiel, Hegewischstrasse 3, 24105, Kiel, Germany.
The objective of this study is to gain a better understanding of the not well understood egg-transportation mechanisms through the female reproductive systems of crabs. For this, Carcinus maenas was chosen as a model to study the cuticular epithelium underlying the cuticle of the vagina and the ventral seminal receptacle. This cuticular epithelium is investigated by performing histochemical and ultrastructural analyses of the epithelial cells.
View Article and Find Full Text PDFWild bees show local spatial and temporal dynamics in southeastern US blueberry farmscapes.
Environ Entomol
January 2025
Department of Entomology, University of Georgia, Tifton, GA, USA.
Wild bee communities are the target of various conservation and ecological restoration programs. Strategic conservation can influence bee communities visiting fields and help mitigate pollinator limitations in fruit production. However, planning compatible conservation strategies and gauging their effectiveness requires understanding how local communities vary across space and time in crops and adjacent semi-natural areas.
View Article and Find Full Text PDFThe impact of air pollution on acute angle-closure glaucoma in Hefei, China, 2017-2022: a time-series study.
J Occup Environ Med
November 2024
Department of Ophthalmology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Objective: The study investigated the effects of air pollutants on the incidence of acute angle-closure glaucoma (AACG) in Hefei, China.Methods: A combination of generalized additive models (GAM) and distributed lag non-linear models (DLNM) was used to explore the relationship between air pollutants and the incidence of AACG.Results: Exposure-response curves showed that exposure to PM2.
View Article and Find Full Text PDFAI Interventions to Alleviate Healthcare Shortages and Enhance Work Conditions in Critical Care: Qualitative Analysis.
J Med Internet Res
January 2025
ETH Zurich, Zurich, Switzerland.
Background: The escalating global scarcity of skilled health care professionals is a critical concern, further exacerbated by rising stress levels and clinician burnout rates. Artificial intelligence (AI) has surfaced as a potential resource to alleviate these challenges. Nevertheless, it is not taken for granted that AI will inevitably augment human performance, as ill-designed systems may inadvertently impose new burdens on health care workers, and implementation may be challenging.
View Article and Find Full Text PDFEffectiveness of the User-Centered "Healthcare CEO" App for Patients With Type 1 Diabetes Transitioning From Adolescence to Early Adulthood: Protocol for a Randomized Controlled Trial.
JMIR Res Protoc
January 2025
Department of Public Health and Primary Care, KU Leuven-University of Leuven, Leuven, Belgium.
Background: Young patients aged 16 to 25 years with type 1 diabetes (T1D) often encounter challenges related to deteriorating disease control and accelerated complications. Mobile apps have shown promise in enhancing self-care among youth with diabetes. However, inconsistent findings suggest that further evidence is necessary to confirm the effectiveness of app-based interventions.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!